HOMOLOGY MODELING OF SHORT CHAIN NEUROTOXINS: AN INITIATION TOWARDS UNDERSTANDING THEIR FUNCTIONAL INFERENCE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objectives: Various types of venoms are being produced by different toxic species which make mild or severe damage to the biological system of target species. The main objective is to disseminate structural information in order to understand the functional importance of the short chain neurotoxins (SCNs).Methods: Computational homology modeling technique is used to predict the theoretical 3D structure of protein. Structural qualities of all predicted SCNs are analyzed using bioinformatics tools.Results: Homology modeling was performed for all selected SCNs (62 toxin proteins) which do not have experimental models in structural databases. Structural folding patterns of all constructed models were further analyzed for exploring the functional role of SCNs. Three dimensional structures of SCNs provide a better understanding of molecular mechanisms that underlies the inhibition of neurotransmitter based potassium ion channels.Conclusion: The retrieved structural information of SCNs will serve as a starting point for designing suitable antidote. Future research is required for analyzing the feasibility of using venomous toxins as a pharmacological agent for several disease targets.Â
Authors and Affiliations
Barani Kumar R, Shanmuga Priya B, Xavier Suresh M, Narendrakumar G
Keywords
Related Articles
- EP ID EP579682
- DOI -
- Views 47
- Downloads 0
BIOLOGICAL IMPORTANCE OF QUINAZOLIN-4-ONE SCAFFOLD AND ITS DERIVATIVES–A BRIEF UPDATE
Heterocyclic compounds form the basis of many pharmaceutical, agrochemical and veterinary products. Among a wide variety of nitrogen heterocyclic moieties that have been explored for developing pharmaceutically useful mo...
PREVALENT RISK FACTORS OF HCV TRANSMISSION IN HEALTH CARE WORKERS (HCWS) IN PAKISTAN
Objective: To study and analyze the prevalent risk factors of Hepatitis C Virus (HCV) transmission in Health Care Workers (HCWs) in PakistanMethods: A literature survey (2005-2012) was conducted from the available litera...
INHIBITORY EFFECTS OF ANCHUSA AZUREA EXTRACTS ON XANTHINE OXIDASE ACTIVITY AND ITS HYPOURICEMIC EFFECTS ON MICE
Objective: The aim of the present study was to determine the effects of the polyphenols and flavonoids from Anchusa azurea on XO activities in vitro and on serum and liver uric acid levels in normal and potassium oxonate...
FORMULATION AND EVALUATION OF CHRONOMODULATED PULSATILE THERAPEUTIC SYSTEM FOR EARLY MORNING SURGE IN BLOOD PRESSURE
Objective: The objective of this study was to design and developed a rupturable coating type of pulsatile press coated tablet, which releases drug early in the morning hours. This delivery system was helpful to control a...
ANALYSIS OF BIOACTIVE CONSTITUENTS FROM A NEW STREPTOMYCES VARIABILIS STRAIN SU5 BY GAS CHROMATOGRAPHY - MASS SPECTROMETRY
Objectives: To analyze the bioactive constituents found in the crude extract of a new Streptomyces variabilis strain SU5 by gas chromatography - mass spectrometry.Methods: A total of fifty two actinomycetes were isolated...