HOMOLOGY MODELLING AND STRUCTURAL ANALYSIS OF HER-2
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
Homology modeling is an in silico technique which has an advantage of building the protein molecules. Her-2 is a protein which is considered has a validate drug target for Breast cancer. Besides Breast Cancer, its overexpression is significantly seen in colorectal cancers, prostate cancer, in the development of the human fetuses and many more. The present paper deals with the Homology Modeling of the Herstatin, a protein from Homo sapiens, its structural analysis and active site prediction. In this pursuit, the experiment proceeds in silico.
Authors and Affiliations
Shailima Vardhini, Siddeshwari Ekke
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4-chloro-3-nitrobenzoic acid was selected as nucleus structure having good antibacterial property. It was thought worthwhile to synthesize Schiff base derivatives of 4-chloro-3-nitrobenzoic acid in search of better antib...