Hormonal Therapy in Breast Cancer: Consideration of Pharmacogenetics
Journal Title: Saudi Journal of Biomedical Research - Year 2017, Vol 2, Issue 4
Abstract
Abstract: Hormonal imbalance in postmenopausal women makes them susceptible to various menopausal symptoms and hormonal replacement therapy (HRT) is the treatment option for them. However, various concerns are involved with this therapy due to increased risk of pulmonary embolism, stroke, coronary heart disease, and even cancer. Especially long term use of single or multiple hormones at the same time appears to be more associated with unwanted disorders. However, few of the reports say that hormonal therapy with estrogens protect women against breast cancer. While there exist wide range of studies to address this issue, genetic profile of the patient are also important prior to HRT. Certain gene profile women are more or less susceptible to cancer risk. In this review we will discuss about various genetic factors related to this issue. Keywords: Hormonal imbalance, postmenopausal women, hormonal replacement therapy (HRT).
Authors and Affiliations
Koch Davis, Falch Wood RW, Robinson JR
Keywords
Related Articles
- EP ID EP387282
- DOI -
- Views 75
- Downloads 0
The Relapse of Single and Mixed Infections of Trypanosoma congolense and Trypanosoma brucei in Red Sokoto Bucks after Treatment with Isometamidium Chloride
Abstract: Field reports by Veterinarians indicate that Isometamidium Chloride used in the treatment of trypanosomosis is not efficacious. This study was designed to determine the efficacy of 2% of this drug in the treatm...
Agro-Morphological Study of four Cultivars of Citrulluslanatus
Abstract:Ivorian Cucurbitaceae seeds consumed in sauce find themselves in several varieties. Among the Cucurbitaceae, Citrulluslanatusspecies comprises four cultivars listed on the basis of the size and appearance of see...
Evaluating of the Drinking Water Quality in Kassala-City, Sudan
Evaluating of the Drinking Water Quality in Kassala-City, Sudan Abstract:Contaminated water may affect the health of millions of residents in the world.The main objective of this research work is to evaluate the drinking...
Gross Anatomical, Histological and Histochemical Studies of the Parathyroid Glands of the African Giant Rat (AGR) (Cricetomysgambianus-Waterhouse, 1840)
Abstract: Twenty AGR (wild African giant pouched rat) comprising of ten males and ten females were used for this study. The average weight of twenty adult African giant rats was observed to be 1058.42 ± 37.79g. The avera...
In Vitro α-Amylase and α-Glucosidase Inhibitory Activity of Methanol Extract of Tolypiocladiaglomerulata(C.Agardh) F. Schmitz
Abstract: The present study is to evaluate the inhibitory activity of α-amylase and α-glucosidase enzymes in the methanol extracts of marine red alga Tolypiocladiaglomerulata. The methanol extract of red alga T. glomeru...