Hormone Therapy in Breast Cancer: Where do We Stand?
Journal Title: Journal of Integrative Oncology - Year 2017, Vol 6, Issue 1
Abstract
Breast cancer is not only the most common malignancy but also the leading causes of cancer-related deaths in women worldwide. The management of breast cancer is subtype driven and determination of hormone receptor [HR] status, a major driving force for the tumor growth is of paramount importance. The use of hormone therapy [HT] to treat HR positive breast cancer is practiced for more than a century and is one of the pivotal examples of precision medicine. The present perspective focuses on the state of the art hormone therapy for early and advanced breast cancer in both pre and post-menopausal women. Recent advances in HT strategies, with respect to single or combination therapy use, adding agents targeting HT resistance, checkpoint inhibitors, and optimal duration of endocrine therapy are also being addressed. Opportunities for individualized patient care are discussed.
Approximation to the Patient with Tumor of Unknown Origin
The tumor of unknown origin constitutes 3-7% of the cancers studied and is one of the 10 most frequent cancer diagnoses. It is a malignant tumor whose first origin or identification is not done in the clinical history, i...
A Case Report "Typhoid Resistant to Chloramphenicol"
Typhoid fever is an infection caused by a strain of bacteria called Salmonella typhi, which is related to the bacteria that causes salmonella food poisoning. The infection can affect the whole body and damage multiple or...
Second Primary Neoplasms: A Clinico-Pathological Analysis from a Sub Himalayan Cancer Centre in India
Background: There is a lifetime risk of developing another de novo malignancy in diagnosed cancer patients. Detection of new primary has increased due to advances in both diagnostic and treatment modalities. This article...
Role of Specific Cancer Treatments in Pain Management
Cancer is characterized by tissue invasion leading to destruction, inflammation, irritation, obstructions and compressions. All these causes of pain may be present in varying degrees in all stages. The pain management th...
Primary Squamous Cell Carcinoma of Breast in a Young Female: An Institutional Experience with Review of Literature
Invasive or infiltrating ductal carcinoma is the most common type of breast cancer while primary squamous cell carcinoma of breast is extremely rare occurring in 0.04%-0.1% of all breast cancer cases known for aggressive...