HOW ARE NEW CARDIOVASCULAR RISK MARKERS PLASMA ATEROGENIC INDEX, NEUTROPHIL / LYMPHOCYTE RATIO AND MONOCYTE HDL RATIO AFFECTED IN OBESITY? A CROSS-SECTIONAL RETROSPECTIVE STUDY
Journal Title: Kocatepe Medical Journal - Year 2022, Vol 23, Issue 1
Abstract
ABSTRACT OBJECTIVE: In World Health Organization (WHO) definition, body mass index (BMI) 25 and over is classified as slightly overweight, 30 and over classified as obese, and obesity has increasing prevalence worldwide. Obesity has become an epidemic and an important in public health problem. In our study, we aimed to investigate the relationship among obesity, a chronic inflammatory and epidemic disease, with the parameters of Neutrophil to lymphocyte ratio (NLR), monocyte to low-density lipoprotein (HDL) ratio (MHR) and atherogenic index of plasma (PAI), which are defined as new inflammation and cardiovascular disease risk markers. MATERIAL AND METHODS: A total of 536 consecutive patients who applied to the primary health care center between 01.12.2018 and 31.04.2019 were evaluated with a retrospective cross-sectional design. The demographic characteristics of the patients, chronic disease characteristics and laboratory, height, weight, waist and hip circumference were obtained from the patient registry database. The patients who admitted participating in the study were divided into four groups according to their BMI as normal weight (18.5-24.9), overweight (25-29.9), obese (30-34.9), and morbidly obese (35 and above). Intergroup variables were evaluated. RESULTS: In the study, the population mean age was 34(IQR 25-42), 84,5% (452) were female. Of the study population 18% (97) were normal weight, 26.5% (142) were slightly overweight, 27.5% (147) were obese, 28.2% (151) were morbidly obese. As obesity was increasing, age(p<0.001), hypertension history(p=0.003) increased significantly. When laboratory parameters were examined, fasting blood glucose level, insulin resistance, C-reactive protein (CRP), ferritin levels increased with obesity severity, while HDL cholesterol was reduced (p<0.001). NLR, MHR, and PAI all parameters increased with obesity, but only PAI reached statistical significance (p<0.001). There was no significant difference between obesity groups in hemoglobin, platelet, vitamin D, vitamin B12 variables. A strong correlation was found between obesity and age, CRP and PAI in the linear regression model. CONCLUSIONS: PAI, one of the parameters we investigated, can be used in clinical practice as a cheap and practical marker to assess cardiovascular disease risk in obese patients. NLR and MHR increased with obesity but did not reach statistical significance.
Authors and Affiliations
İbrahim ERSOY Pınar ERSOY
Keywords
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- EP ID EP699138
- DOI https://doi.org/10.18229/kocatepetip.793923
- Views 100
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