How can we predict steatosis using biochemical markers (SteatoTest and Fatty liver index)
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2011, Vol 3, Issue 2
Abstract
Objective: The aim of this study was to establish the diagnostic performance of two biological markers - fatty liver index (FLI) and SteatoTest, in identifying hepatic steatosis and assessing its degree.Material and Methods: Seventy seven patients with biopsy-proven non-alcoholic fatty liver disease(NAFLD) were prospectively studied and compared with 18 healthy subjects. The patients were stratifiedaccording to the degree of hepatic steatosis. Two biochemical markers, FLI and SteatoTest, were determined. The diagnostic value of each method was assessed using sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV) and the area under the receiving operating characteristics curve (AUROC). Results: We found that both markers are able to recognize the presence of NAFLD. These are the values obtained for SteatoTest (controls: 0.176±0.0079, NAFLD: 0.744±0.166, p<0.001) and for FLI (controls: 80.29±10.53, NAFLD: 91.1±1.89, p<0.001). The AUROC for the diagnosis of steatosis was 0.811 for SteatoTest (Se: 90.32%, Sp: 67.74%, PPV: 77.8%, NPV:84.8%) and 0.808 for FLI (Se: 98.33%, Sp: 54.55%, PPV: 94.7%, NPV: 79.7%). We also found SteatoTest and FLI useful for the discrimination between insignificant (S0 and S1) and significant steatosis (S2 and S3) (p<0.001). Conclusion: SteatoTest and FLI are accurate and easy to use markers for the diagnosis of steatosis and they allowed differentiation between mild/moderate and severe steatosis.
Authors and Affiliations
Corina Radu, Dana Crişan, Mircea Grigorescu
Mast-cell rich perivascular dermatitis accompanying the ulcerative lesions resulting from infection of Staphylococcus aureus in C57BL/6 mice
The purpose of this study was to investigate the health status of mice and rats in our laboratory animal facilities. In addition, the author encountered sporadic cases of the ulcerative skin lesions, and then the dermato...
Pathological changes and clinical use of the measurement of serum/plasma concentrations of insulin-like growth factor type 1 (IGF-1) in horses, dogs and cats.
The biological effects of the growth hormone are in part mediated by the release of insulin-like growth factor type 1 (IGF-1) by the liver but also from other non-hepatic tissues. As opposite as GH, IGF-1 is not release...
Iron deficiency anemia: online methods of patient educatio
The authors present some of the most important online patient education methods in English on iron deficiency anemia (easy-to-read articles, information leaflets, easy-to-understand fact sheets, newsletters, patient...
The genetic characteristics of extended-spectrum β-lactamases (ESBLs) among Escherichia coli and Klebsiella pneumoniae isolates from urine specimen
Background & objectives: Extended spectrum β-lactamases (ESBLs) have emerged as a major threat worldwide with limited treatment options. The genotypes of ESBL producing strains largely remain unknown in Romania;...
The evaluation of inherited thrombophilic conditions in patients with bleeding in the first trimester of pregnancy.
Introduction: Prothrombotic condition induced by inherited thrombophilia is involved in vascularization disorders of the placenta bed. The aim of our study was to investigate the relationship between the presence of spec...