HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ARTEMETHER AND LUMEFANTRINE TABLETS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 2
Abstract
A simple and precise HPLC method was developed and validated for estimation of artemether and lumefantrine in fixed-dose combination tablets .The quantification was carried out using C18 (150x4.6mm) analytical column. A mobile phase of acetonitrile and 0.02M potassium dihydrogen ortho phosphate (80:20 v/v) was adjusted to pH 3.0 with 0.2% ortho phosphoric acid, was used. The flow rate was 1.5 cm3 min -1, and the detector wavelength was 199 nm. The linear calibration range was 80-120%, and the correlation coefficient was 0.999. The relative standard deviation for six replicates was less than 2.0%. However, the retention times were 3.1 min and 1.97min, and the recovery range were 97.89 - 99.69% and 98.48 – 101.15%, for artemether and lumefantrine, respectively.
Authors and Affiliations
Noon Kamal Saeed
Keywords
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- EP ID EP651166
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