HsCRP And Serum Zinc Levels In Type 2 Diabetes Mellitus And Their Correlation With GLYCEMIC Status
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 2
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world. Type 2 DM represents a significant global health problem. Metabolically triggered inflammation has been proposed as a key step in the pathogenesis of this disease and accelerate atherosclerosis and premature death in subjects. C-reactive protein is an acute phase reactant protein., which is found elevated and serum zinc levels are lower in T2DM. Objectives: To estimate hsCRP (high sensitivity C reactive protein) and serum zinc levels in cases and controls and to compare and analyze the levels of these parameters between two groups. Methods: A case control study conducted on 80 patients with clinically diagnosed T2DM and age and sex matched 80 apparently healthy subjects as controls from the general population. 3ml of venous blood was collected to study hsCRP and serum zinc levels in each subject. The data was analyzed and expressed in terms of mean ± SD. Results: There was statistically highly significant increase in the levels of hsCRP (p < 0.0001) and statistically highly significant decreased levels of serum zinc (p < 0.0001) in cases and there was highly significant positive correlation between hsCRP – HbA1c levels in cases. There was highly significant negative correlation between serum zinc – HbA1c levels in cases. Interpretation & Conclusion: It can be concluded that hsCRP which had diagnostic utility and correlated well with HbA1c, could be used as a good diagnostic tool and serum zinc could be considered as a supportive diagnostic tool in T2DM.
Authors and Affiliations
Dr . Mamatha B. V, Dr. Leela P, Dr. Chandrakanth K. H, Dr. Kashinath R. T
Keywords
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- EP ID EP415074
- DOI 10.9790/264X-0403010104.
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