Serum H Pylori Antibodies and Thyroid Disorder in Chronic Urticaria
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2018, Vol 4, Issue 2
Abstract
Introduction:Chronic urticaria(CU) is the most common pruritic condition with multiple casual factor characterized by erythamatous, edematous and pruritic lesion of dermis and hypodermis 50% of patients with chronic urticaria have autoimmune basis. Thyroid disorders and H pylori have been a major contribution to chronic urticaria. AIMS and objectives: To estimate RBS, H pylori IgG, IgM, TSH in patients with chronic urticaria and comparing with control group. To evaluate the importance of these biochemical parameters in chronic urticaria patients. Methodology:30 patients with symptoms of chronic urticaria and 28 controls were considered for the study. Random Blood samples was collected and evaluated for H pylori IgG, IgM, RBS and TSH. H pylori antibodies was analysed by Elisa method. TSH was estimated by immunoassay method and RBS by hexokinase- G6PD method. Results:RBS in cases and controls was 119.07 ± 62.9 and 90.67 ± 11.17, respectively with significant p value of 0.022. TSH in cases and controls was 4.11 ± 2.26 and 2.47 ± 1.42, respectively with significant p value of 0.02. H pylori IgG in cases and controls was 0.83 ± 0.58 and 0.46 ± 0.43, respectively with significant value of 0.034. H pylori IgM in cases and controls was 0.79 ± 0.55 and 0.52 ± 0.35, respectively, with significant value of 0.028. Conclusion:RBS, TSH, H pylori IgG and IgM was significantly high in cases than controls, suggesting a strong role of diabetes, and autoimmune role in urticaria.
Authors and Affiliations
Shantha Kumari . N, Karthik G, Nataraj B
Keywords
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