Human carcinoembryonic antygen family proteins, structure and function

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2012, Vol 66, Issue 0

Abstract

The CEA related cell adhesion molecules (CEACAM) contain variable and constant immunoglobulin-like domains and are classified as a member of the immunoglobulin supergene family, IgSF. The seven CEACAM (CD66) antigens (CEACAM1, CEACAM3, CEACAM4, CEA, CEACAM6, CEACAM7 and CEACAM8) differ in the number of Ig-like domains, sugar content, presence of isoforms, tissue distribution and form of membrane attachment (transmembrane region or GPI anchor). CEACAMs with a transmembrane region possess a cytoplasmic domain with or without the immunoreceptor motifs. The structural diversity of CEACAMs results in their multifunctionality, especially displayed in calcium independent homo- and heterotypic adhesion interactions. The scientific data, collected mainly for CEA, strongly confirm involvement of this molecule in colorectal cancer. Recent research also indicates that CEACAMs play an important role in signal transduction, recognition and binding of pathogenic bacteria belonging to Neisseria and Escherichia genera.

Authors and Affiliations

Hanna Czepczyńska-Krężel, Anna Krop-Wątorek

Keywords

Related Articles

Effects of lactoferrin on elicitation of the antigen-specific cellular and humoral cutaneous response in mice

Immune contact dermatitis is an inflammation of the skin resulting from exposure to allergens in the environment. The aim of this study was to compare the actions of lactoferrin (LF), a natural immunomodulator, on the el...

Photodynamic therapy in head and neck cancer

Photodynamic therapy (PDT) is a special type of treatment involving the use of a photosensitizer or a photosensitizing agent along with a special type of light, which, combined together, induces production of a form of o...

Epigenetyka a etiologia chorób neurodegeneracyjnych

Kluczem do morfologicznego i funkcjonalnego zróżnicowania komórek w obrębie ludzkiego organizmu jest ustalanie specyficznych wzorców ekspresji genów. Genom ludzki zawiera około 25–30 tys. genów, przy czym w każdej komórc...

Rare clinical form of glioblastoma multiforme

Glioblastoma multiforme (glioblastoma multiforme - GBM) is the most malignant tumor classified by WHO. It is also the most common primary CNS tumor with a very aggressive course and unfavourable prognosis, usually develo...

Hipomelanocytozy dziedziczne: rola genów PAX3, SOX10, MITF, SNAI2, KIT, EDN3 i EDNRB

Jednymi z najcięższych schorzeń dermatologicznych, dotykających pacjentów ze wszystkich regionów świata, są choroby wynikające z hipo- i hiperpigmentacji. Zaburzenia te można podzielić na melanozy, związane z nieprawidło...

Download PDF file
  • EP ID EP66741
  • DOI -
  • Views 154
  • Downloads 0

How To Cite

Hanna Czepczyńska-Krężel, Anna Krop-Wątorek (2012). Human carcinoembryonic antygen family proteins, structure and function. Advances in Hygiene and Experimental Medicine, 66(0), 521-533. https://europub.co.uk/articles/-A-66741