Human membrane transporter database: A web-accessible relational database for drug transport studies and pharmacogenomics
Journal Title: The AAPS Journal - Year 2000, Vol 2, Issue 3
Abstract
published July 14, 2000
Authors and Affiliations
Qing Yan, Wolfgang Sadée
High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability
Stabilization and formulation of therapeutic proteins against physical instability, both structural alterations and aggregation, is particularly challenging not only due to each protein’s unique physicochemical c...
Pharmacokinetics in mice implanted with xenografted tumors after intravenous administration of tasidotin (ILX651) or its carboxylate metabolite
The pharmacokinetics of tasidotin (ILX651), a depsipeptide currently in phase II for the treatment of advanced solid tumors, and tasidotin-C-carboxylate, the main metabolite, were characterized in male nude mice implante...
Erratum to: Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells
The online version of the original article can be found at 10.1208/s12248-013-9550-y.
Pharmacogenomics: The promise of personalized medicine
Genetic variations in human G protein-coupled receptors: Implications for drug therapy
Numerous genes encode G protein-coupled receptors (GPCRs)-a main molecular target for drug therapy. Estimates indicate that the human genome contains approximately 600 GPCR genes. This article addresses therapeutic impli...