Human VKORC1 2255T>C polymorphism: distribution analysis in a Romanian population
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2012, Vol 4, Issue 3
Abstract
The present paper analyses for the first time the distribution of the 2255T>C vitamin K epoxide reductase complex subunit 1 (VKORC1) gene polymorphism in a population of Romanian descent. A cohort of 120 healthy subjects has been genotyped using a PCR-RFLP protocol. Within the studied population, 48 individuals were found to be CC homozygotes (40%), 16 were TT homozygotes (13.33%), while 56 subjects were heterozygous (46.67%); the genotype distribution being in accordance with Hardy-Weinberg equilibrium (χ2=0.0001; df=1). The 0.37 frequency of the minor allele is consistent with the generally described frequencies of other VKORC1 polymorphisms in Caucasian populations, providing further evidence for strong linkage disequilibrium between this gene’s polymorphisms.
Authors and Affiliations
Mihai Șuteu, Bogda Georgescu, Carmen Georgescu
Keywords
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