Hydrazine Documentation of proposed values of occupational exposure limits (OELs)
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2015, Vol 31, Issue 3
Abstract
Hydrazine is a liquid used in various industries.In 2011 in Poland, approximately 2000 people were exposed to hydrazine and its salts.This compound is strongly irritating to the eyes, skin and respiratory system.Hydrazine has been classifi ed to a carcinogen category 1.B. Carcinogenicity of hydrazine has been proven in animals. The results of exposure were benign and malignant tumors of the nasal cavity, lungs and liver. There is no conclusive evidence of carcinogenicity in humans.In Poland, TWA of 0.05 mg/m[sup]3[/sup] and STEL of 0.1 mg/m[sup]3[/sup] are valid. The ACGIH TLV proposedvalue of 0.013 mg/m[sup]3[/sup]. The SCOEL did not establish normative values because proper effectsto assess toxicity of hydrazine are carcinogenic and genotoxic effects. The assessment of possibleeffects in humans is not possible because of interspecific differences in the carcinogenic effects onthe upper airways. The European Union propose a binding BOELV value of 0.013 mg/m[sup]3[/sup].Animal studies suggest that a liver is a critical organ as a result of exposure to hydrazine. The results of studies of chronic inhalation exposure of Syrian hamsters to hydrazine were used to determine the value of MAC-NDS. The critical effects were hepatotoxic: amyloidosis, hemosiderosisand proliferation of bile ducts. The LOAEL value is 0.332 mg/m[sup]3[/sup].Derived limit value is 0.014 mg/m[sup]3[/sup] and the STEL value is 0.042 mg/m[sup]3[/sup] because of the irritant effects.Labeling as Carc. 1.B (carcinogenic category 1.B), „Skin” and „I”(irritant) was suggested.After discussion and voting at the 77th meeting of the Interdepartmental Commission for MAC andMAI (January 14, 2015) exposure limit value TWA of 0.013 mg/m[sup]3[/sup] and STEL value of 0.039 mg/m[sup]3[/sup]was accepted. This values are consistent with binding values adopted by the ACSH.
Authors and Affiliations
MAREK JAKUBOWSKI, MAŁGORZATA KUPCZEWSKA-DOBECKA
Keywords
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