HYDROGEN SULFIDE SYSTEM ATTENUATES INJURY BY HYPERGLYCEMIA AND STRESS: ROLE OF MESENTERIC ADIPOCYTES IN AGED ANIMALS
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2018, Vol 52, Issue 2
Abstract
The mesentery is one of recently described separate organs which functions and its ability to protect injury are still unclear. Adipocytes are a part of mesentery (MAC), however, it is a little known about their age-related changes, reactive response during damage induced by hyperglycemia, stress, and their interaction. Hydrogen Sulfide (H2S) system is key endogenous cytoprotectvite system that operated by catalytic activities of Cystathionine-γ-lyase (CSE), Cystathionine-β-synthase (CBS), and Sulfite Oxidase (SUOX) but their role in adipocyte cytoprotection are still unknown. To evaluate the CBS, CSE, SUOX activities in the mesenterium and ultrastructural changes of MAC in aged rats fed with HSD, at stress induction, and modification of H2S synthesis by NaHS and hybrid nonsteroid anti-inflammatory drugs H2S-acytylsalicylic acid (H2S-ASA).
Authors and Affiliations
Oleh Revenko, Natalia Zaichko, John Wallace, Oksana Zayachkivska
Keywords
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- EP ID EP495621
- DOI 10.25040/ntsh2018.02.115
- Views 78
- Downloads 0
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