HYDROPHILIC POLYMERIC MATRIX TABLET FOR SUSTAINED DELIVERY OF LEVOFLOXACIN
Journal Title: International Journal of Pharmaceutical Science and Technology - Year 2010, Vol 5, Issue 2
Abstract
Purpose of undertaken research activity is to prepare a hydrophilic matrix system based, technologically optimized, sustained release (SR) tablet of levofloxacin (1000 mg) for once-a-day dosing, having adequate physicochemical stability. Different grades of hydrophilic polymer; i.e., hydroxypropyl methylcellulose (HPMC) like: Hypromellose E15, Hypromellose K4M, Hypromellose K15M, were utilized to prepare SR tablets; employing matrix dispersion technique and using additives like lactose, maize starch, sodium starch glycollate, magnesium stearate and purified talc. Film coating of tablets was done with aqueous coating solution containing Hypromellose E5 as the film former and titanium dioxide & yellow oxide of iron as the color so as to provide light protection. Tablets were evaluated for compliance to Indian Pharmacopoeia (IP)-2007 specifications. The difference factor (f1), the similarity factor (f2) and the rescigno index (ξ1 and ξ2) of model-independent approaches were determined for comparing pair of in-vitro dissolution profiles. From in-vitro dissolution profile plot, values for the kinetic constant and the regression coefficient (r2) of model-dependent approaches were determined to find the best fit release kinetic model. Film coated SR tablets of levofloxacin was successfully developed employing formulation F3, complying IP-2007 specifications, that had exhibited adequate stability and had controlled & extended levofloxacin release following zero order kinetic with satisfactory stability at room temperature. Experimental results suggest that the drug release rate from SR tablet depends on the grade and the concentration of hydrophilic polymer.
Authors and Affiliations
Sk. Md. Athar Alli , Amalesh samanta , Biswajit mukherjee , Sk. Md. Ajhar Ali , Gourhari Dehury
Keywords
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- EP ID EP114206
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