Hyperbilirubinemia during Atazanavir treatment in HIV/AIDS patients taking second line ART drugs
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 1
Abstract
Background Hyperbilirubinemia is frequently observed in HIV (Human Immunodeficiency Virus) patients treated with Atazanavir containing antiretroviral regimen in the dose of 300 mg once daily. However, little is known about the incidence of Atazanavir-associated hyperbilirubinemia in Asian population. Hyperbilirubinemia is defined as an excess of bilirubin in blood either conjugated or unconjugated. Aim To estimate the incidence of Atazanavir associated hyperbilirubinemia in HIV patients receiving second line antiretroviral regimen advocated by National AIDS Control Organisation (NACO) by measuring serum bilirubin levels. Materials and Methods The study was done in 100 HIV-infected patients attending ART Plus centre at a tertiary care centre receiving Atazanavir regimen for a period of 12 months. The bilirubin levels in blood were estimated by MALOY & EVELYN METHOD. Results The incidence of grade I hyperbilirubinemia was 26%, grade II was 24%, grade III was 48% & grade IV 2%. The Study data suggested that Atazanavir-associated hyperbilirubinemia is common and self limiting. Conclusion It was observed that most of the HIV/AIDS patients receiving Atazanavir containing ART regimens developed hyperbilirubinemia, so these patients should be regularly monitored for Atazanavir induced hyperbilirubinemia.
Authors and Affiliations
Savithri Desai
Keywords
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