Hyperhomocysteinemia and Alcoholism: A Double Hit?
Journal Title: Toxicology and Forensic Medicine – Open Journal - Year 2017, Vol 2, Issue 2
Abstract
Homocysteine (HCY) is a non-protein sulfur-containing amino acid. It has received a great deal of attention over the last two decades within the scientific community for its unique role in the induction of several diseases ranging from atherosclerotic cardiovascular disease to neural tube defects (NTD). The hypothesis that hyperhomocysteinemia (HHCY) causes atherosclerosis was proposed by McCully1 in 1969, when he observed that children with homocysteinuria had atherosclerotic plaques of the peripheral, coronary, and cerebral vasculature. In 1976, the initial epidemiological study of Wilcken and Wilcken 2 supported this hypothesis and provided the first evidence of the pathogenic role of HCY in atherosclerotic cardiovascular disease and alcoholism. HCY strictly associated with alcohol consumption and enhanced the alcohol consumption that leads to alcohol-related disorders such as brain atrophy, epileptic seizures during withdrawal, and mood disorders.3 Although, HHCY involves both genetic and nutritional causes,4 the mechanism of HCY toxicity is not completely understood.
Authors and Affiliations
Bashir M. Rezk
Keywords
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- EP ID EP550851
- DOI 10.17140/TFMOJ-2-123
- Views 127
- Downloads 0
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