Toxicology of Mixtures - Cd +PCBs Experimental Model
Journal Title: Toxicology and Forensic Medicine – Open Journal - Year 2016, Vol 1, Issue 1
Abstract
Humans are exposed to hundreds of thousands of chemicals from very different sources and the presence of more than 200 xenobiotics has been so far determined in human blood or urine.1 Hence, exposure assessment and toxicological evaluation should be focused on mixtures rather than on single chemicals. The importance of “cocktail effects” evaluation is summarized in European Commission statement that highlighted that even low level exposure to a complex cocktail of pollutants over decades can have significant effect on the health status of European citizens.2 Although, toxicity studies and risk assessments are focused on single chemicals, research on the toxicology of mixtures have emerged decades ago. Actually, more than thirty years ago United States Environmental Protection Agency (EPA) published Guidelines for the Health Risk Assessment (HRA) of Chemical Mixtures3 and after a few years Technical Support Documents and Guidance Manuals4,5 followed by the efforts of Agency for Toxic Substances and Disease Registry (ATSDR)6 and Organisation for Economic Cooperation and Development (OECD).7 However, although a certain progress has been made, the toxicology of mixtures remains a matter of great concern and challenge for the scientific community.
Authors and Affiliations
Vesna Matović
Keywords
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- EP ID EP551427
- DOI 10.17140/TFMOJ-1-e004
- Views 115
- Downloads 0
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