Hyperhomocysteinemia As A Risk Factor For Atherosclerosis In Chronic Kidney Disease
Journal Title: International Journal of Basic and Applied Physiology - Year 2013, Vol 2, Issue 1
Abstract
Background: The role of Hyperhomocysteinemia (HHomocysteine)as a risk factor for atherosclerosis in Chronic kidney disease (CKD) has gained much interest worldwide.The primary objective of the study was to ascertain the association between serum homocysteine levels and GFR. Method :This case control study was done in stage 3,4 and 5 of CKD (cases= 63 ,controls =21) to assess the association between Serum homocysteine (S.Homocysteine),Serum creatinine(S.Cr),Glomerular Filtration Rate(GFR) and Carotid intima media thickness (CIMT). Result: Statistical analysis using ANOVA and pearsons correlation revealed a significant association between S.Homocysteine and stages of CKD (p=0.00),S.Homocysteine and GFR (p=0.00 ,rsq=0.3686) S.Homocysteine and CIMT (p=0.002, rsq=0.1429) and CIMT and CKD (p=0.00). Conclusion:On the basis of these observations ,it was concluded that HHomocysteineexists in CKD and that it produces atherosclerosis . Hence early screening and treatment for HHomocysteine and atherosclerosis should be done in CKD to prevent cardiovascular diseases
Authors and Affiliations
Reshmi raju, Ambika P, Ramdas Pisharody
Keywords
Related Articles
- EP ID EP542503
- DOI -
- Views 51
- Downloads 0
RELATIONSHIP OF ANTHROPOMETRIC VARIABLES WITH FASTING BLOOD SUGAR IN MODERATE AND SEDENTARY WORKERS
Background: Failure to engage in physical activity constitutes the fourth most important risk factor leading to death in the entire world. Modernization has resulted in increased rates of diabetes, primarily because of a...
BIOCHEMICAL AND ANTIOXIDANT EFFECTS OF TALINUM TRIANGULARE (WATER LEAF) IN FEMALE SPRAGUE -DAWLEY RATS
Therapeutic properties of medicinal plants are very useful in the treatment and healing various diseases and the advantaged of these plants is been 100% natural with little or no side effects. The present study seeks to...
A COMPARATIVE EVALUATION OF RESPIRATORY INDICES IN PETROL STATION WORKERS OF AGARTALA.
The study was conducted on 32 nonsmoker healthy petrol pump workers within 20-50 years age group working in different petrol stations of Agartala with 32 age and sex matched healthy controls from general population. Pulm...
EFFECT OF UPPER BODY FAT DISTRIBUTION ON PULMONARY FUNCTIONS IN MEDICAL STUDENTS.
Background: The prevalence of obesity is increasing, and there is evidence that obesity, in particular abdominal obesity as a marker of insulin resistance, is negatively associated with pulmonary function. The mechanism...
STUDY OF PULMONARY FUNCTION TESTS IN SICKLE CELL ANAEMIA PATIENTS IN BOTH SEXES IN RAIPUR DISTRICT, CHHATTISGARH
:Background: The inherited disorders of haemoglobin are the commonest single gene disorder of the world population. Sickle cell anaemia being the most widespread and numerically the most important haemoglobinopathy in th...