BIOCHEMICAL AND ANTIOXIDANT EFFECTS OF TALINUM TRIANGULARE (WATER LEAF) IN FEMALE SPRAGUE -DAWLEY RATS
Journal Title: International Journal of Basic and Applied Physiology - Year 2017, Vol 6, Issue 1
Abstract
Therapeutic properties of medicinal plants are very useful in the treatment and healing various diseases and the advantaged of these plants is been 100% natural with little or no side effects. The present study seeks to investigate the biochemical and antioxidant effects of aqueous leaf extract of Talinum triangulare (water leaf) in female Sprague -Dawley rats. Twenty Four (24) female Sprague -Dawley rats weighing 150-180gram were grouped into 4 of 6 rats each. Group A: control; administered (10ml/kg body weight) of normal saline. The other groups were administered the aqueous leaf extract of Talinum triangulare thus: group B -50mg/kg, group C - 100mg/kg, and group D – 150mg/kg. After fourteen (14) days, blood samples were collected for lipid and antioxidant analysis. The results revealed significant increase in AST (aspartate amino transferase) at 150ml/kg, when compared with the group A S(P>0.05). The ALT (alanine amino transferase) was significantly decreased (P>0.05) at 100ml/kg when compared with group A and group B with significant elevation at 150ml/kg. The ALP (alkaline phosphatase) was significantly increased in all the tested doses (P>.0.05). Results from the lipid profile analysis showed significant decrease in all the doses tested (P>0.05) for cholesterol (CHOL), triglyceride (TG) and high density lipoprotein (HDL) levels except for CHOL and HDL which showed significant increase (P>0.05) at 150ml/kg. The low density lipoprotein (LDL), protein, and albumin levels showed significant increase in the tested doses expect, protein and albumin which was significantly decreased (P>0.05) at 100ml/kg and 150ml/kg. Also the creatinine level was significantly decreased in all the doses tested (P>0.05). The antioxidant assay revealed significant increase in glutathione, GSH, superoxide dismutase, SOD and Catalase, CAT (P>.05) at all doses, expect SOD which was significantly decreased at 150mg/kg. The malondialdehyde, MDA was significantly decreased (P>0.05) in all the tested doses. Our findings showed that aqueous leaf extract of Talinum triangulare administration at 50mg/kg, 100mg/kg and 150mg/kg have no adverse effect on renal functions. However, at 150ml/kg the aqueous leaf extract of Talinum triangulare gave rise to increase in liver enzymes' activity, increased low density lipoprotein as well as oxidative radical productions. Finally excessive intake should be avoided since it is dose dependent because of its ability to increase risk of obesity, cardiovascular disorder and liver damage.
Authors and Affiliations
Y. D. Igbayilola, A. O. Morakinyo, A. W. Ewetayo, W. A. Saka
Keywords
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