HYPERLIPAEMIC AND HYPERGLYCAEMIC EFFECTS OF A METABOLIC PEPTIDE HORMONE FROM THE NEURONAL TISSUES OF THE MANGO LEAF WEBBER ORTHAGA EXVINACEA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
The peptide hormone present in the brain-retrocerebral complexes of the mango leaf webber Orthaga exvinacea (Pyralidae: Lepidoptera) belonging to the adipokinetic hormone/red pigment-concentrating hormone family have different functions. The activity of the hormone extract tested both in vivo (heterologous bioassays against the polyphagous plant bug Iphita limbata) and in vitro clearly indicated that they are involved in lipid (adipokinetic hormones) and carbohydrate (hyperglycaemic hormones) release by activating fat body lipase and glycogen phosphorylase respectively. Injection of hormone extract (5 µl) containing one gland pair equivalent (gpe) elicited significant hyperlipaemic (up to 15%, P<0.001) and hyperglycaemic effects (up to 18%, P<0.05), whereas in the control, injection of 5 µl of insect saline did not evoke any such effects. The brain-retrocerebral complex extract showed significant effect on fat body lipid mobilization (up to 17%, P<0.05) and fat body sugar release (up to 18%, P<0.001). HPLC separation of the peptides followed by analysis of the fractions for activities confirmed that the peptide hormone extracted has a pivotal role in the mobilization of these metabolites.
Authors and Affiliations
Umadevi D. , Gokuldas M. , Ajaykumar A. P.
Keywords
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