HYPERTHERMIA AS A TRIGGER FOR ACTIVATION OF HORMETIC MECHANISMS
Journal Title: Science Review - Year 2018, Vol 4, Issue 3
Abstract
Hyperthermia is widely used in oncology clinic. In combination with radio- and chemotherapy, it allows substantially reduce the doses of named treatment modalities and appropriately - their negative side effects. In case of metastasized tumors, the whole body hyperthermia (WBH) is used. We do not know how WBH can affect the brain functions (learning and memory), and also the rheological properties of blood. The study of these issues was our main goal. Experiments on rats have shown that WBH in the range of 38-450C did not alter the temperature in the brain tissue (370C) as well as memory processes. At the same time, dramatic stimulation of locomotor and searching activity of rats has been observed. Analysis of received data allows concluding that we observed the behavioral manifestation Phenomenon of Hormesis. This result makes possible to use WBH not only as temperature action on cells, but also as a very effective trigger mechanism for activation of this phenomenon.
Authors and Affiliations
N. Mitagvaria, L. Davlianidze, M. Devdariani, I. Kvachakidze
Keywords
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