HYPOLIPIDEMIC POTENTIAL OF RAW SEEDS OF DACRYODES EDULIS ON WISTAR RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 6
Abstract
The phytochemical screening of ethanol extract of Dacryodes edulis seeds and its effect on lipid profile of albino Wistar rats was investigated. Fresh seeds were obtained, air-dried at room temperature and pulverized. The powder was macerated in 80% ethanol and the filtrate was concentrated to obtain crude extract. The crude extract was subjected to phytochemical screening and also administered to albino Wistar rats. Twenty-four (24) albino Wistar rats weighing between 150 – 180g were obtained and randomly selected into 4 groups with 6 animals in each group. Group I served as control while Groups II, III and IV served as test groups and were administered 100, 200 and 300 mg/kg body weight of the extract respectively, daily for 14 days by use of cannula attached to a syringe. All the animals were allowed access to rat feed and clean water ad libitum. Result show that the seed extract has a wide array of phytochemicals which include saponins, flavonoids, terpenes, alkaloids, tannins, cardiac glycosides and phlobatannins. Triglyceride, total cholesterol, LDL-cholesterol and VLDL-cholesterol concentrations were significantly reduced following the administration of the extract to Wistar rats while a dose dependent increase was observed in HDL-cholesterol concentrations. The ethanol extract of seeds of Dacryodes edulis is rich in phytochemicals and have a positive lipid modulatory effects.
Authors and Affiliations
Jessie Idongesit Ndem
Keywords
Related Articles
- EP ID EP628665
- DOI -
- Views 181
- Downloads 0
EXPERIENCE OF UNDERGRADUATE MEDICAL STUDENTS IN COMMUNITY FIELD TRAINING IN QASSIM, SAUDI ARABIA
Background: A field training community based course was established to achieve the college‟s mission of imparting community oriented education. The main training locations were government primary health care (PHC) center...
KNOWLEDGE OF PEOPLE ABOUT THE TUBERCULOSIS INFECTION IN THE HEALTH CENTER IN BAGHDAD
Background: Tuberculosis is the second-most common cause of death from infectious disease (after those due to HIV/AIDS). Aims: To identify the knowledge of people about TB disease in the health center, and to find out an...
ANTIOXIDANT PROFILES OF ALCOHOLIC TINCTURES FROM HETEROTIS ROTUNDIFOLIA (SM.) JACQ.-FÉL. (MELASTOMACACEAE) BY DPPH RADICAL TRAPPING
Phytophenols are widely distributed in the vegetable kingdom. This is the reason why, for the first time, we evaluate the phenolic compound content and the antioxidant profile Heterotis rotundifolia alcoholic tinctures,...
PHYSICOCHEMICAL CHARACTERIZATION OF BUDESONIDE FOR NANOPARTICLES PREPARATION.
Preformulation studies and characterization are known as a special fundamental Physico-chemical properties of the drug such as drug solubility, stability, melting point, and drug partitioning. Preformulation studies can...
FAST DISSOLVING ORAL FILM: OVERVIEW
The purpose of the current review is to enlighten the present and the future prospective on oral fast dissolving films (OFDFs) as a drug delivery system as they are gaining interest as a substitute of fast dissolving tab...