PHYSICOCHEMICAL CHARACTERIZATION OF BUDESONIDE FOR NANOPARTICLES PREPARATION.
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 3
Abstract
Preformulation studies and characterization are known as a special fundamental Physico-chemical properties of the drug such as drug solubility, stability, melting point, and drug partitioning. Preformulation studies can help in selecting formulation approach to develop effective, stable, and economic dosage forms. Fundamental Preformulation studies include development of a suitable analytical method for drug analysis, determination of drug solubility, determination of drug stability at different stress conditions which may be applied during the preparation of formulations, determination of water/octanol partition coefficient, measurement of melting point and drug excipients compatibility. Physicochemical properties of budesonide such as aqueous solubility in deionized water, different buffer solutions, and solutions containing surfactants were determined. Partition coefficient using water/ octanol system at different pH values were calculated.Forced degradation studies under different stress conditions such as acid, alkali, photo, oxidative, and neutral conditions were studied using LC-MS-MS spectrophotometer. Budesonide showed aqueous solubility of 0.02566 mg/mL with increased solubility to some extent upon using tween 80. Budesonide have a partition coefficient of 2.14 with good drug stability under different stress conditions except higher alkali conditions in which drug completely degraded into another product. Physicochemical studies for the poorly soluble budesonide offered a suitable data for the preparation of nanoparticles.
Authors and Affiliations
Dr. Usama Farghaly Ali
Keywords
Related Articles
- EP ID EP635529
- DOI -
- Views 185
- Downloads 0
GELUCIRE IN DRUG DELIVERY SYSTEMS
Lipids based drug delivery system is a multidisciplinary approach, a assembly of organic chemistry, physics, biopharmaceutical and formulation technologies encompassing the role of fatty acids, fatty acid esters, and the...
HANDHELD DEVICES (HHD) USE AMONG FAMILY MEDICINE RESIDENTS IN RIYADH CITY, KSA
Background: Among health care providers, especially physicians, the use of Handheld Devices (HHD) including smartphones and tablets has evolved since the handheld devices technology keeps improving. There are specific ap...
EFFECT OF LONG -TERM CONSUMPTION OF SUCROSE, ASPARTAME AND STEVIA SWEETENERS ON HIPPOCAMPUS ANTIOXIDANT DEFENSE STATUS
Stevia leaf extract has the potential to be used as a non-caloric natural sweetener instead of the synthetic sweetener aspartame due to its antioxidant potency in controlling free radicals with resultant health benefits...
PREVALENCE AND DISTRIBUTION OF CANDIDA ISOLATES FROM HIGH VAGINAL SWAB SAMPLES OF SOME WOMEN IN NNEWI, ANAMBRA STATE, NIGERIA.
Candida species normally colonize the skin and mucosal surfaces of humans in an asymptomatic manner but can become a most significant cause of disabling and lethal infection in immuno-suppressed persons. This study was d...
UNUSUAL FATTY ACIDS INCORPORATED INTO NATURAL PEPTIDES DERIVED FROMSEAWEEDS AND INVERTEBRATES
This review is a first comprehensive survey focuses on theunique, unusual and rare fatty acids incorporated into natural peptides derived from seaweeds and invertebrates. Fatty acids incorporated into lipopeptides are of...