Identification of De Novo peptide and motif prediction on Hypothyroidism protein (FOXE1) using insilico tools
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2016, Vol 6, Issue 2
Abstract
Internationally about one billion people are estimated to be iodine deficient; however, it is unknown how often this results in hypothyroidism. In this present research investigation, we focus on the potential motif sequence for the mutated gene coded protein related to hypothyrodism disorder. The FOXE1 peptide sequence modeling is based on the Helix-Turn-Helix (HTH) motif sequence. We used advanced peptide modeling server for methodology studies. The final results of our project clearly explain that the identified motif –peptide sequence and the 3D peptide structure are potential candidates for drug docking studies and also act as novel molecular markers useful for pharmacoinformitics and clinical endocrinology studies.
Authors and Affiliations
Hepzibah. W , John William S , Balaji. M
Keywords
Related Articles
- EP ID EP118241
- DOI -
- Views 101
- Downloads 0
Pharmacognostic evaluation of whole plant of [i]Sida spinosa [/i]linn. (Malvaceae)
Pharmacognostic evaluation of whole plant of Sida spinosa Linn. was carried out to determine the macroscopical and microscopical characters, determination of leaf content, extractive value, fluorescence analysis, ash ana...
Motif And Domain Comparative Studies on Human Lung (CHRNA5) And Liver (NAT2) Cancer Disease Using Bioinformatics Protocols
Eastern Europe has the highest lung cancer mortality among men, while northern Europe and the US have the highest mortality among women. In the United States, black men and women have a higher incidence. Lung cancer rate...
Protein modelling, identification of de novo chemical inhibitor and QSAR studies on PCOS (Polycystic Ovary Syndrome) using cheminformatics software and tools
In this Insilico research project, Polycystic Ovary syndrome analysis was carried out. Protein modeling and drug designing were major steps for delivering the best drug candidates for disease target. The identified prote...
Pharmacognostical studies on leaves of [i]Stephania japonica[/i] var. Timoriensis
[i]Stephania japonica[/i] (Thunb). (Syn S. harnendifolia) is a species under the genus of climbers belonging to family Menispermeceae. It is used in traditional medicinal practices and is locally known as Tubuki lota or...
Protein –protein docking studies on diabetes mellitus using insilico methods
Concurrent with the spread of the western lifestyle, the prevalence of all types of diabetes is on the rise in the world's population. The number of diabetics is increasing by 4-5% per year. It was long believed that the...