Protein –protein docking studies on diabetes mellitus using insilico methods
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2014, Vol 4, Issue 1
Abstract
Concurrent with the spread of the western lifestyle, the prevalence of all types of diabetes is on the rise in the world's population. The number of diabetics is increasing by 4-5% per year. It was long believed that the effects of insulin are mediated by a unique insulin receptor. There is at present no available drug other than insulin itself to activate directly insulin receptors. It is hoped that these expanded choices will provide the tools necessary for a more efficient management of diabetes and it’s prevalent. In this study we are focused to find out the binding efficiency between the bovine and porcine insulin with the insulin receptor. In this project first the number of binding regions in the insulin receptor was found using CASTP server. From the CASTP analysis we found 110 pockets were present in the insulin receptor structure. Then the analysis was carried out to find out the minimum energy required for binding the protein molecules like bovine and porcine insulin with the insulin receptor using HEX software. The analysis results show that the bovine insulin needs minimum energy of (-334.84) when compared with the porcine insulin binding energy of (-201.13) for producing maximum effect. We also considered the binding energy of these two proteins. The bovine insulin requires the binding energy of -5.62 and the porcine insulin requires 2.69.From the above analysis we concluded that the bovine insulin possess maximum binding capacity with minimum of energy requirements than the porcine insulin.
Authors and Affiliations
Srina. S , S. Sugunakala
Keywords
Related Articles
- EP ID EP154195
- DOI -
- Views 88
- Downloads 0
Molecular sequence similarity and motif prediction studies on S. Oryzae-outer membrane component of tripartite multidrug resistance system and Tribolium castaneum- translocase of outer membrane using bioinformatics method
In bioinformatics, sequence alignment is a way of arranging the sequences of DNA, RNA, or protein in order to identify regions of similarity that may be a consequence of functional, structural or evolutionary relationshi...
[u][/u]Analysis on creatinine reducing herbals renal as protective agents in rat
Tribulus terrestris (Nerunji mullu), Butea monosperma (Parasa pattai) and Chicorium intybus (Kasini keerai) are the traditional herbal medicines used in Siddha and Ayurvedic system. They are analyzed for their creatini...
Identify the molecular functional regions and protein modeling studieson potential protein target (outer membrane component of tripartite multidrug resistance system) Sitophilus oryzae using in silico protocols
Despite extensive study, little is known about the origins of the mutualistic bacterial endosymbionts that inhabit approximately 10% of the world's insects. In this research we focus on the molecular functional regions a...
Pharmacognostical studies on leaves of [i]Stephania japonica[/i] var. Timoriensis
[i]Stephania japonica[/i] (Thunb). (Syn S. harnendifolia) is a species under the genus of climbers belonging to family Menispermeceae. It is used in traditional medicinal practices and is locally known as Tubuki lota or...
Identification de novo motif and sequence alignment studies on the (Liver cancer -STA13, Lung cancer-CHRNA5 and Colon cancer-MLH1) using In silico protocols
Worldwide, as of 2010, liver cancer resulted in 754,000 deaths, up from 460,000 in 1990, making it the third leading cause of cancer death after lung and stomach. Globally, lung cancer is the most common cancer among men...