Imatinib mesylate resistance in Chronic Myelogenous Leukemia cells may be overcome by Indian Spice Curcumin
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
Imatinib mesylate (IM), the drug used in chronic myeloid leukemia (CML) therapy, acts by targeting the Philadelphia chromosome (Bcr-Abl). A disadvantage of IM is development of drug resistance. Expression of various tumor markers like Bcr–Abl, TNF-α, NF-κB, Interleukins(IL-6, IL-8, IL-10), JAK2, STAT3, ERK1/2, PI3K, AKT are anomalously expressed in CML. In IM-resistant CML, having high expression of p-glycoprotein and MRP, levels of these markers are even more aberrant. This study aims to develop a means to overcome drug-resistance using nontoxic phytochemical curcumin, which is a common Indian spice. K-562R, a drug resistant population was developed from parental K-562 by exposing cells to gradually increasing doses of IM. IM regulates the tumor markers and induces apoptosis in K-562 cells; presence of curcumin enhances the effect. IM, showed no/little effect on aberrant expression of tumor markers in K-562R cells; however, inclusion of curcumin along with the drug, efficiently regulates these biomarkers, leading to induction of apoptosis even in drug-resistant CML cells. Results obtained indicate that curcumin administration may help to overcome IM-resistance in CML cells. The study highlights the potential of curcumin in combating the problem of drug resistance in leukemia therapy.
Authors and Affiliations
Madhumita Roy
Keywords
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