Imbalance of kallikrein-kinin system in chronic pancreatitis combined with obesity and results of its comprehensive correction

Journal Title: Гастроентерологія - Year 2017, Vol 51, Issue 4

Abstract

Background. Chronic pancreatitis is one of the most common diseases in general therapeutic practice. Significant role in the onset and progression of chronic pancreatitis is played by the activation of the kallikrein-kinin system (KKS), which is involved in the development of inflammation, blood coagulation and fibrinolysis, immune responses, the formation of pain, etc. Objective: to investigate the dynamics of indicators of the kallikrein-kinin system when using metadoxine in the comprehensive therapy of patients with chronic biliary pancreatitis associated with obesity. Materials and methods. 75 patients with chronic biliary pancreatitis combined with obesity were examined. They were divided into 2 groups. The first group (30 people) received the standard treatment. The second group (45 people) received the standard treatment and metadoxine. Results. Analyzing the results, it has been found a reliable positive dynamics of KKS indices in both groups after the treatment. However, patients in the second group showed a more significant positive dynamics of KKS parameters: the level of proteolytic activity has decreased by 9.0 %, the kallikrein — by 20.0 %, α1-proteinase inhibitor — by 7.2 %, and prekallikrein has increased by 6.4 %, α2-macroglobulin — by 10.8 %, kininase II — by 10.7 % as compared to group 1. Conclusions. The use of methadoxine in the comprehensive therapy of patients with chronic biliary pancreatitis associated with obesity contributed to a significant increase in the effectiveness of conventional treatment.

Authors and Affiliations

L. S. Babinets, K. Yu. Kytsai

Keywords

Related Articles

The Role of Bismuth in the Treatment of Gastroduodenal Pathology (Literature Review and Own Researches)

The article presents the history of colloidal bismuth subcitrate and considers the basic mechanisms of its effects on the gastric mucosa, both cytoprotective and anti-helicobacter. The recent data of the worldwide resear...

Practical Approaches to the Management of Patients with Dyspepsia

The article deals with the problem of the treatment of dyspepsia syndrome. Since recently the majority of patients with functional dyspepsia have a combination of symptoms of epigastric pain syndrome and postprandial dis...

Oxidant-Antioxidant Homeostasis in Gastroduodenopathies Induced by Nonsteroidal Anti-Inflammatory Drugs in Patients with Osteoarthritis Taking into Account the Pathogenic Helicobacter pylori Strains

The role of Helicobacter pylori (Hp) in pathogenetic mechanisms of gastroduodenopathies (GDP) caused by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) is ambiguous. The aim of the work...

Past, present and future of surgical treatment of peptic ulcer (50-year experience of the institute)

The article presents the literature data and the results of the author’s own research on the development of peptic ulcer surgery in the historical aspect. It is shown that the evolution of the knowledge about the etiopat...

Anorexia nervosa: Review and Clinical Case

The article deals with an actual problem — anorexia nervosa. The authors consider this problem taking into account up-to-date knowledge and recommendations concerning anorexia nervosa. Data on the prevalence, criteria of...

Download PDF file
  • EP ID EP249357
  • DOI 10.22141/2308-2097.51.4.2017.119289
  • Views 92
  • Downloads 0

How To Cite

L. S. Babinets, K. Yu. Kytsai (2017). Imbalance of kallikrein-kinin system in chronic pancreatitis combined with obesity and results of its comprehensive correction. Гастроентерологія, 51(4), 246-248. https://europub.co.uk/articles/-A-249357