Age-Dependent Features of Certain Pro- and Anti-Inflammatory Cytokines in the Blood of Patients with Nonviral Liver Cirrhosis

Journal Title: Гастроентерологія - Year 2014, Vol 1, Issue 51

Abstract

Age-dependent features of tumor necrosis factor α, interleukin-4 and transforming growth factor β1 in the blood of patients with liver cirrhosis and their correlation with biochemical markers of liver injury were studied. It was found that in patients with liver cirrhosis cytokine system underwent significant changes. This resulted in increased blood plasma concentration of tumor necrosis factor α and transforming growth factor β1 compared with apparently healthy patients and in age-dependent increase of these cytokines. The blood content of interleukin-4 in patients with liver cirrhosis was reduced compared with controls, age-dependent changes of this cytokine concentration in blood weren’t detected. Correlation between the proinflammatory cytokine plasma levels and biochemical markers of cytolytic, cholestatic and mesenchymal-inflammatory syndromes was established, indicating a significant role of cytokine component of the immune system in the development and progression of liver cirrhosis.

Authors and Affiliations

V. P. Prysyazhnyuk

Keywords

Related Articles

Liver Stiffness According to Data of Shear Wave Elastography in Patients with Diabetes Mellitus Type 2 and Nonalcoholic Fatty Liver Disease Depending on Activity of NAFLD

Shear wave elastography is one of the most promising non-invasive methods for diagnosis of fibrosis and steatosis in chronic diffuse liver diseases, which can be used as an alternative to biopsy. Given its widespread int...

Epidemiologic and Therapeutic Aspects of Chronic Diffuse Liver Diseases in Servicemen

In the article we had analyzed the results of statistical accounting on morbidity, structure and approaches to treatment of chronic diffuse liver diseases (CDLD) in servicemen. It is shown that CDLD take second ranking p...

Functional Dyspepsia and Irritable Bowel Syndrome: What Is Similar?

The article presents the analysis of main functional diseases of digestive system — ​functional dyspepsia and irritable bowel syndrome. There was shown the similarity of pathogenic factors of these diseases. Besides trad...

Doctors-Devotees in the Field of Zemstvo Medicine

Zemstvo medicine as a form of medical service to rural population appeared in the second half of the XIX century. Zemstvo was responsible for taking care of public health, medicine became a social service. The developmen...

Download PDF file
  • EP ID EP225020
  • DOI -
  • Views 78
  • Downloads 0

How To Cite

V. P. Prysyazhnyuk (2014). Age-Dependent Features of Certain Pro- and Anti-Inflammatory Cytokines in the Blood of Patients with Nonviral Liver Cirrhosis. Гастроентерологія, 1(51), 37-43. https://europub.co.uk/articles/-A-225020