IMMUNE STATUS OF CHILDREN WITH EXTRAHEPATIC PORTAL HYPERTENSION AFTER PERFORMANCE OF DIFFERENT TYPES OF PORTOSYSTEM SHUNTING OPERATIONS
Journal Title: Ukrainian Scientific Medical Youth Journal / Український Науково-Медичний Молодіжний Журнал - Year 2012, Vol 69, Issue 3
Abstract
The paper is focused on the features and grade of changes in the immune system under the extrahepatic portal hypertension and after splenorenal and mesocaval shunting operations. The investigation was performed on 17 children, in whom the cell, humoral and unspecific pats of immune system were evaluated. The leading pathological factors were defined. It was established that there is significant tensity in the humora part (IgÌ, Ig A) and phagocytosis, secondary cell immune deficiency with decreasing of general number of lymphocytes and subpopulations of lymphocytes (ÑD3+, ÑD4+, ÑD8+). Immunological parameters after splenorenal shunting were improved (approached to the age norms) comparing to those after mesocaval shunting. However, the operative treatment essentially doesn’t improve the condition of the immune system. Therefore, the parameters of immunogramme should be considered while monitoring such category of patients, selection of the immunocorrective and detoxication therapy for prevention of postoperative complications and for the further management under extrahepatic portal hypertension.
Authors and Affiliations
K. Dzhuma, A. Dubrovin,, V. Prytula, O. Godik, M. Ishenko
Keywords
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