Immunochromatographic test versus microscopy in diagnosis of severe P. falciparum malaria
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 1
Abstract
Objective: Primary objective of this study was to compare diagnostic advantage of immunochromatographic test over peripheral blood smear microscopy in clinically suspected severe falciparum malaria. Methods: In this prospective study, total 125 clinically suspected severe malaria cases were enrolled during a period of two years from June 2014 to May 2016.All patients were subjected to peripheral blood smear microscopy and Paracheck Pf antigen detection test. Results: Total 180 cases were enrolled in study, of which 156 proved to be cases of severe plasmodium falciparum malaria diagnosed by either peripheral smear examination or Pf HRP-2 rapid malaria antigen test. Remaining 24 cases were excluded from the study. The sensitivity and positive predictive value of immunochromatographic Paracheck Pf test taking microscopy as reference standard was 91.28% and 95.10% respectively. Conclusion: HRP-2 based rapid diagnostic test for falciparum malaria has high sensitivity (91.28%) and positive predictive value (95.10%).
Authors and Affiliations
Ramrao Mundhe, Prashant Patil, Maroti Karale, Shivraj Mane
Keywords
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