Immunohistochemical analysis of caveolin-1 antigen distribution in patients with malign and benign breast disease
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 6
Abstract
Abstract: Breast cancer is the most common cancer among women and most common cause of cancer related mortality and morbidity. Breast cancer oncogenesis has many pathways involved. Caveolin-1 is a component of the caveolae and is the key molecule involving strategic signalling molecules in the pathogenesis of breast cancer. The aim of the present study is to evaluate the distribution of Caveolin-1 antigen in specimens obtained from benign and malignant breast cancers. On this study tissue samples obtained from benign breast disease (n=203) and malignant breast disease (n=98) was subjected to immunohistochemical staining and positive areas separately for stromal components and epithelial component of the tumour.Caveolin-1 expression was 1746.78±981.89 and 1457.31±1331.91 in the benign and malignant tumour groups respectively. When the benign group was evaluated independently; it was observed that highest expression was observed in the sclerosing adenosis. Among the malignant breast cancer group invasive ductal carcinomas and mucinous carcinoma had the highest expression. Stromal comments were stained predominantly. Caveolin-1 expression loss was seen in malignant lesions. This suggests the tumour suppressor function of this gene for mammary carcinoma oncogenesis. Keywords:Breast, Malign, Benign, Oncogenesis, Tumour suppressor gene, Caveolin-1, Tumour Stroma, Malign, Benign.
Authors and Affiliations
Hasan Bostanci, TevfikTolga Sahin, Kursat Dikmen, AynurAlbayrak Sonmez, AhmetVolkan Yildirim, Aydin Yavuz
Keywords
Related Articles
- EP ID EP373133
- DOI -
- Views 66
- Downloads 0
Broad Ligament Leiomyoma Mimicking As Ovarian Tumor
We report two cases of broad ligament leiomyoma. Extrauterine leiomyoma remains an uncommon site to occur. Usually these tumors remains asymptomatic. When the lesion became large they present with various clinical man...
Sonographic Estimation of Gestational Age by using Transcerebellar Diameter in Second and Third Trimester of Pregnancy
The accurate knowledge of gestational age is a keystone in an obstetrician's ability to successfully manage the antepartum care of a patient and is of critical importance in ante-natal tests and successful planning of ap...
A Study of the Effect of Trans-Urethral Resection of Prostate on the Erectile Function of the Patients in Eastern Indian Population
There has been a continuing debate on the effect of transurethral resection of prostate (TURP) on the erectile function (EF) of the patient. This study aims to study the effect of TURP on the EF of the patient at 3 month...
Spurious Macrocytosis- Automated Cell Counters are Not Fool-Proof
With increasing use of electronic hematology cell counters macrocytosis is often encountered. Various etiological factors contribute to the development of macrocytosis. This study is from Kerala State, India and is a ret...
A Comparative Study on Intra Operative Problems during Primary versus Repeat Caesarean Sections
Caesarean section (CS) is the most common surgery done in obstetric practice. After any laparotomy, it is fairly common to develop scar tissue, adhesions and bladder extension, CS holds no exception to this. Multiple CS...