Immunohistochemical Correlation with Morphological Evolution of Urinary Bladder Tumors
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 4
Abstract
Context: Urinary bladder diagnosis can be challenging and conventional markers used were cytokeratins. The new additions are GATA 3, uroplakin and S100P. This study helps to analyze immunohistochemical expression of panel of markers across the spectrum of urinary bladder tumors. Aims: 1. to evaluate immunohistochemical expression in various subtypes of urothelial neoplasms of the urinary bladder and to correlate this expression with the grade of the tumor. 2. To distinguish between reactive urothelium and carcinoma in situ/ dysplasia using immunoprofile work up. Settings and Design: Study was performed in the department of Pathology in RGCIRC, Delhi with 70 cases of urinary bladder lesions during period of one year. Methods and Material: longitudinal study Statistical Analysis: The tissue sections were scored using CK, UROPLAKIN II, GATA 3, S100P, CD44, p16 and KI 67 Results: 1. CK7+ and CK20+in 92% and 77% cases. p16+ in 83% and CD 44+ in 84%. Newer markers: Uroplakin II-75%; S100P-82% and GATA3-96%positivity. CD44+ in reactive urothelium 5/5 and CK20+ in CIS (12/12) cases. p16+ in 4/5 cases of reactive atypia and CIS 12/12 cases. Conclusions: The markers are sensitive for urothelial origin & have to be used as panel wherever required.
Authors and Affiliations
Dargar Parul
Keywords
Related Articles
- EP ID EP520572
- DOI 10.21088/ijprp.2278.148X.7418.4
- Views 89
- Downloads 0
Efficacy of Triple Test Score in Evaluation of Breast Lumps: A One Year Prospective Study
Introduction: The Triple test score includes triad of clinical examination, imaging studies and FNAC to arrive at a diagnosis. In TTS each component of the triple test score is rated as benign, suspicious or malignant an...
Clinico-morphological Correlation and Diagnostic Accuracy of Synovial Biopsy in Synovitis: Experience in Tertiary Care Hospital
Synovium is a specialized mesenchymal tissue in which varied pathological lesions can occur, but most common are non neoplastic lesions. Aim of the Study: To determine histopathological spectrum of non-neoplastic lesions...
Cytology of Malignant Lesions of Liver: An Institutional Study
Background and Objectives: The evaluation and management of various hepatic lesions is a common clinical problem and their appropriate management depends on accurate diagnosis. Aim of the study is to study the cytomorpho...
A Comparative Study of Intubating Conditions between PropofolFentanyl-Midazolam and Propofol-Fentanyl-Lignocaine Groups without Neuromuscular Blocking Agents
Introduction: Tracheal Intubation without the use of neuromuscular blocking drugs was used to assess the airway by laryngoscopy. We compared the effect of midazolam and lignocaine on intubating conditions along with prop...
Noise Pollution
N\A