Immunohistochemical Correlation with Morphological Evolution of Urinary Bladder Tumors
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 4
Abstract
Context: Urinary bladder diagnosis can be challenging and conventional markers used were cytokeratins. The new additions are GATA 3, uroplakin and S100P. This study helps to analyze immunohistochemical expression of panel of markers across the spectrum of urinary bladder tumors. Aims: 1. to evaluate immunohistochemical expression in various subtypes of urothelial neoplasms of the urinary bladder and to correlate this expression with the grade of the tumor. 2. To distinguish between reactive urothelium and carcinoma in situ/ dysplasia using immunoprofile work up. Settings and Design: Study was performed in the department of Pathology in RGCIRC, Delhi with 70 cases of urinary bladder lesions during period of one year. Methods and Material: longitudinal study Statistical Analysis: The tissue sections were scored using CK, UROPLAKIN II, GATA 3, S100P, CD44, p16 and KI 67 Results: 1. CK7+ and CK20+in 92% and 77% cases. p16+ in 83% and CD 44+ in 84%. Newer markers: Uroplakin II-75%; S100P-82% and GATA3-96%positivity. CD44+ in reactive urothelium 5/5 and CK20+ in CIS (12/12) cases. p16+ in 4/5 cases of reactive atypia and CIS 12/12 cases. Conclusions: The markers are sensitive for urothelial origin & have to be used as panel wherever required.
Authors and Affiliations
Dargar Parul
Keywords
Related Articles
- EP ID EP520572
- DOI 10.21088/ijprp.2278.148X.7418.4
- Views 82
- Downloads 0
Use of PDCA Cycle in Improving Compliance to Universal Safety Precautions in a Medical College Laboratory
Introduction: We studied effectiveness of PDCA cycle in improving compliance of laboratory staff with respect to universal safety precautions. Material and Methods: We noted compliance of staff to safety precautions like...
Fetal Autopsies and its Significance: A Tertiary Care Center Study
Introduction: Perinatal mortalityworldwide accounts for about 53/1000 total births [1], in which preterm births contribute to a major proportion, followed by other fetal, placental and maternal factors [2]. Hence, analyz...
Evaluation of Utility of Cytospin Technique in Fine Needle Aspirations
Fine needle aspiration cytology (FNAC) is an important diagnostic tool used preoperatively for diagnosis of palpable and non palpable mass lesions. Various techniques have been described for doing the procedure. Aims & O...
A Clinicopathological Spectrum of Soft Tissue Tumors in a Tertiary Care Centre with Emphasis on Role of Immunohistochemistry in Diagnosis of Soft Tissue Tumors
Background: In diabetic patients incidence of cardiovascular disease due to thrombosis is higher than healthy individual. PT, aPTT and Platelet count are haematological parameters that give an idea about the coagulation...
A Rare Case of Cutaneous Lymphangiectasia of the Vulva Secondary to Tuberculosis
We present an interesting case of acquired cutaneous lymphangiectasia of vulva following tubercular lymphadenitis. It was a 35 year old lady who initially had cervical lymphadenitis proven positive for Tuberculosis and r...