Immunohistochemical expression of cyclooxygenase-2 in uterine serous carcinoma tissue
Journal Title: Journal of Interdisciplinary Histopathology - Year 2016, Vol 4, Issue 1
Abstract
Objective: The aim of the present study was to assess cyclooxygenase-2 (COX-2) expression in uterine serous carcinoma (USC) tissue, to correlate it with clinicopathological prognostic factors in order to assess whether selective COX-2 inhibitors may be effective in the treatment in this tumor. Materials and Methods: COX-2 expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014. Staining of more than 10% of the cells was considered positive. Staining intensity was graded on a 0-3 scale. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Clinicopathological data were retrospectively abstracted from the records of the study group patients. Results: The study comprised uterine specimens of 31 USC patients. Positive immunohistochemical staining was observed in 25 (80.6%), USC specimens and a high score in 6 (19.4%) of them. No association between immunohistochemical staining parameters and clinicopathological prognostic factors was observed. Conclusion: Although our findings should be verified in larger series, it seems that in view of the lack of association between immunohistochemical COX-2 staining parameters in USC tissue and clinicopathological prognostic factors; this aggressive tumor is not a candidate for the use of selective COX-2 inhibitors.
Authors and Affiliations
Joseph Menczer, Letizia Schreiber, Esther Berger, Tally Levy
Keywords
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- EP ID EP123016
- DOI 10.5455/jihp.20150923115314
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