Immunohistochemical expression of cyclooxygenase-2 in uterine serous carcinoma tissue
Journal Title: Journal of Interdisciplinary Histopathology - Year 2016, Vol 4, Issue 1
Abstract
Objective: The aim of the present study was to assess cyclooxygenase-2 (COX-2) expression in uterine serous carcinoma (USC) tissue, to correlate it with clinicopathological prognostic factors in order to assess whether selective COX-2 inhibitors may be effective in the treatment in this tumor. Materials and Methods: COX-2 expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014. Staining of more than 10% of the cells was considered positive. Staining intensity was graded on a 0-3 scale. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Clinicopathological data were retrospectively abstracted from the records of the study group patients. Results: The study comprised uterine specimens of 31 USC patients. Positive immunohistochemical staining was observed in 25 (80.6%), USC specimens and a high score in 6 (19.4%) of them. No association between immunohistochemical staining parameters and clinicopathological prognostic factors was observed. Conclusion: Although our findings should be verified in larger series, it seems that in view of the lack of association between immunohistochemical COX-2 staining parameters in USC tissue and clinicopathological prognostic factors; this aggressive tumor is not a candidate for the use of selective COX-2 inhibitors.
Authors and Affiliations
Joseph Menczer, Letizia Schreiber, Esther Berger, Tally Levy
Keywords
Related Articles
- EP ID EP123016
- DOI 10.5455/jihp.20150923115314
- Views 86
- Downloads 0
Protective efficacy of antioxidants on cisplatin-induced tissue damage caused in Leishmania donovani infected BALB/c mice against murine visceral leishmaniasis
Objective: Therapeutic interventions against visceral leishmaniasis (VL) are limited and facing serious concerns of toxicity, high cost and emerging resistance, there is a greater interest in new drug developments which...
Primary epithelioid angiosarcoma of the adrenal gland: Report of a case and review of the literature
Primary mesenchymal neoplasms of the adrenal gland are extremely rare. The most common primary sarcoma is adrenal angiosarcoma. We report the case of a 51-year-old patient who presented with left flank pain. After ultras...
Nodule over Arm during Pregnancy: An Unusual Presentation of Filariasis
The aim of the article is to present a rare case of filariasis presenting as a nodule over arm in a pregnant lady which was diagnosed by fine needle aspiration cytology. Lymphatic filariasis is a major public health prob...
Cytokeratin 7 and Antimitochondrial Antibody Expressions in the Differential Diagnosis of Renal Epithelial Neoplasms with Eosinophlic Cytoplasm
Objectives: The distinction between epithelial renal tumors with eosinophilic cytoplasm, namely, chromophobe renal cell carcinoma (ChRCC), clear cell (conventional) renal cell carcinoma (ECRCC) with eosinophilic cytoplas...
Synchronous superfi cial myofi broblastoma and stromal polyp of the vagina: Report of a case supporting common histogenesis of both lesions
Rare simultaneous occurrence of vaginal superficial cervicovaginal myofibroblastoma and vaginal stromal polyp is described. The lesions were found in a 90-year-old patient, in the anterior wall of the vagina. The diamete...