Immunohistochemical expression of cyclooxygenase-2 in uterine serous carcinoma tissue
Journal Title: Journal of Interdisciplinary Histopathology - Year 2016, Vol 4, Issue 1
Abstract
Objective: The aim of the present study was to assess cyclooxygenase-2 (COX-2) expression in uterine serous carcinoma (USC) tissue, to correlate it with clinicopathological prognostic factors in order to assess whether selective COX-2 inhibitors may be effective in the treatment in this tumor. Materials and Methods: COX-2 expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014. Staining of more than 10% of the cells was considered positive. Staining intensity was graded on a 0-3 scale. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Clinicopathological data were retrospectively abstracted from the records of the study group patients. Results: The study comprised uterine specimens of 31 USC patients. Positive immunohistochemical staining was observed in 25 (80.6%), USC specimens and a high score in 6 (19.4%) of them. No association between immunohistochemical staining parameters and clinicopathological prognostic factors was observed. Conclusion: Although our findings should be verified in larger series, it seems that in view of the lack of association between immunohistochemical COX-2 staining parameters in USC tissue and clinicopathological prognostic factors; this aggressive tumor is not a candidate for the use of selective COX-2 inhibitors.
Authors and Affiliations
Joseph Menczer, Letizia Schreiber, Esther Berger, Tally Levy
Keywords
Related Articles
- EP ID EP123016
- DOI 10.5455/jihp.20150923115314
- Views 92
- Downloads 0
Cytokeratin 7 and Antimitochondrial Antibody Expressions in the Differential Diagnosis of Renal Epithelial Neoplasms with Eosinophlic Cytoplasm
Objectives: The distinction between epithelial renal tumors with eosinophilic cytoplasm, namely, chromophobe renal cell carcinoma (ChRCC), clear cell (conventional) renal cell carcinoma (ECRCC) with eosinophilic cytoplas...
Undifferentiated Sarcoma Induced by BCNU (1,3-bis(2-chloroethyl) -1-nitrosourea) Wafers
Malignant gliomas are the most aggressive type of brain tumor, with poor prognosis after recurrence. The most common site of recurrence is within two centimeters of the resection margin. BCNU (1,3-bis(2-chloroethyl)-1-ni...
Sirenomelia - Mermaid syndrome with oesophageal atresia: A rare case report
Sirenomelia or Mermaid syndrome is a very rare congenital deformity in which legs are fused together and commonly associated with abnormal kidney development, genital, and rectal abnormalities. In this present case, sire...
Plasmablastic lymphoma: A report of 2 cases with review of literature
Plasmablastic lymphoma (PBL) is an aggressive subtype of non-Hodgkin lymphoma initially described in extra-nodal sites in an immunocompromised and later in immunocompetent patients. PBL remains a diagnostic challenge due...
Fine Architectonics and Protein Turnover Rate in Myofibrils of Glucocorticoid-Caused Myopathic Rats
Objective: The purpose of this study was to assess the relationship between the synthesis and degradation rate of thick and thin myofilaments, and changes in fine architectonics of myofibrils of glycolytic muscle fibers...