Undifferentiated Sarcoma Induced by BCNU (1,3-bis(2-chloroethyl) -1-nitrosourea) Wafers
Journal Title: Journal of Interdisciplinary Histopathology - Year 2013, Vol 1, Issue 3
Abstract
Malignant gliomas are the most aggressive type of brain tumor, with poor prognosis after recurrence. The most common site of recurrence is within two centimeters of the resection margin. BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) wafers (“BCNU wafers”) are used to deliver local high dose chemotherapy around the resection cavity, and serve as a treatment option for treating malignant gliomas in an effort to delay tumor recurrence. We present the case of a fifty three year old woman who developed rapidly progressive sarcoma in her bone flap after the placement of BCNU wafers. Initially the patient underwent resection and conventional radio-chemotherapy treatment for her disease. Once the glioma recurred, a new resection was performed and the patient underwent placement of BCNU wafers. Soon after the placement of the BCNU wafers, an aggressive sarcoma developed in the patient’s bone flap which eroded rapidly through her scalp. The patient died soon after her sarcoma diagnosis. As the patient’s bone flap was not exposed to any mutagens, such as radiation or chemotherapy, and the only chemotherapy the bone flap came into contact with was the nitrosourea from the BCNU wafers, we believe that the local chemotherapy was directly responsible for inducing the rapidly expanding sarcoma which ultimately led to the death of the patient.
Authors and Affiliations
Daniela Alexandru, Mark Linskey, Ronald Kim
Keywords
Related Articles
- EP ID EP130631
- DOI 10.5455/jihp.20130116012102
- Views 112
- Downloads 0
Unusual Presentation Hides the Diagnosis of Soft Tissue Sarcomas
Soft tissue sarcomas are always challenging lesions. This study is aimed to stress on unusual presentation of sarcoma patients that may cause significant delay in the diagnosis to provide appropriate therapy. Two subsets...
Bilateral adenomyoepithelioma of the breast presenting with breast abscess in a lactating woman: A case report
The term adenomyoepithelioma has been applied to a broad range of biphasic lesions composed of epithelial and myoepithelial cells. They show diverse morphologic patterns due to the admixture of the two components which m...
Cytokeratin 7 and Antimitochondrial Antibody Expressions in the Differential Diagnosis of Renal Epithelial Neoplasms with Eosinophlic Cytoplasm
Objectives: The distinction between epithelial renal tumors with eosinophilic cytoplasm, namely, chromophobe renal cell carcinoma (ChRCC), clear cell (conventional) renal cell carcinoma (ECRCC) with eosinophilic cytoplas...
P53 immunohistochemical staining patterns in benign, premalignant and malignant lesions of the oral cavity: A study of 68 cases
Objectives: The p53 tumor suppressor gene is a frequent target for mutations in a variety of tumors. The mutated gene is more stable than the normal gene and can be detected by immunohistochemical methods. The aim of the...
Cytomegalovirus endometritis in a non-immunosuppressed patient presenting as recurrent pyometra: A case report
Cytomegalovirus infection of the female genital tract is a rare entity. We present a case of 70-year-old woman who came with recurrent pyometra but was otherwise in good health. Hysterectomy was done, and the endometrium...