Immunohistochemical expression of EP-CAM in different histopathological grades of oral squamous cell carcinoma.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Background: oral squamous cell carcinoma(OSCC) is the most common type of head and neck cancer. The main etiological factor is found to be tobacco and other habits like betel nut, alcohol etc. Normal epithelial cell surface contains membrane glycoproteins which mediate cell to cell interaction and cellular recognition. Epithelial cell adhesion molecule(Ep-CAM) plays role in cell proliferation, invasion and metastasis. High Ep-CAM expression is found as the early finding in malignant transformation and can be used as marker for diagnostic purpose. Aims and objective: Assessment of EP-CAM expression pattern and distribution in OSCC and normal oral mucosal tissue. Material and method: The sample consisted of 40 cases and divided into three groups of different grades of OSCC and one group of normal oral mucosal tissue, ten in each group. All cases are immunohistochemically evaluated for the pattern and distribution of Ep-CAM using anti Ep-CAM antibody on the formalin fixed paraffin embedded tissue section by standardimmune histochemistry (IHC) technique and statistical analysis done. Results: No statistical difference was obtained when the comparison was done in all four groups for pattern of expression and significant statistical difference was observed when comparison done for distribution of Ep-CAM. Conclusion: The increase in Ep-CAM expression from normal mucosa to OSCC was observed, therefore Ep-CAM can be used for diagnostic or therapeutic purpose but further studies needed with large samples to establish same.
Authors and Affiliations
Sharana basappa
Keywords
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