Immunohistochemical expression of Ki-67 in invasive breast carcinoma and its correlation with prognostic parameters
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 5
Abstract
Background: Ki-67 expression is strictly associated with cellular proliferation and is an excellent marker for determining the growth fraction of a given cell population. It may be considered as alternative to mitotic counts in grading schemes and as a single parameter that can be used in fine needle aspirates and small biopsies. The aim of this study was to evaluate proliferative fraction of Ki67 expression in invasive breast carcinoma and to find out the correlation between Ki67 expression and clinico-pathological prognostic factors such as tumor size, lymph node status, histological grade and Nottingham prognostic index. Materials and Methods: Seventy cases of infiltrating ductal carcinoma breast were studied. Immunohistochemistry using the anti-Ki-67 antibody [MIB-1] was performed on all cases and Ki-67 staining was categorized as low and high grade. Result: High expression of Ki-67 was found in 71.05% cases of breast tumor with positive lymph node metastasis and 92.31% cases of Grade III tumor. Ki-67 expression was significantly associated with nodal status (p<0.0001) and poorly differentiated tumor (p<0.0001). Although, Ki-67 expression was associated with tumor size, but their correlation was not statistically significant (p= 0.065). Conclusion: High Ki-67 expression was associated with a higher grade of malignancy. Conclusively, proliferative activity determined by Ki-67 expression may reflect the aggressive behavior of breast carcinoma. Ki-67 detection provides valuable information about proliferative activity of cells so, it is necessary to combine this with other parameters for better prognosis.
Authors and Affiliations
Rashmi Jain, Reeni Malik, V. K. Trichal, Ankit Jain, Minu Bakna
Keywords
Related Articles
- EP ID EP230131
- DOI 10.17511
- Views 134
- Downloads 0
Study of clinical profile of tuberculosis in HIV infected patients with special reference to CD4 T cell count and its oral manifestation
Aim: To study the clinical profile of tuberculosis in HIV infected patients and to compare the different clinical data with their CD4 counts with reference to oral health. Material Methods: Total 100 cases attending Depa...
Histopathological study of breast lesions
Abstract Objectives: To study the histopathological features of neoplastic and non neoplastic lesions of breast. To correlate the pathological findings with clinical parameters. Design and methods: We have studied total...
Methotrexate Induced Toxic Epidermal Necrolysis: A Case Report
Methotrexate continues to be one of the most widely used systemic immunosuppressive agents in dermatology. We describe a case of low-dose methotrexate (MTX) toxicity in a patient with chronic plaque psoriasis occurring d...
Interstitial lung diseases - a tertiary care center experience
Introduction: Interstitial lung diseases are a group of diffuse parenchymal lung disorders associated with substantial morbidity and mortality and pose diagnostic and therapeutic challenges to the clinician. Diagnosis of...
Intravenous methylprednisolone versus intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy: an randomized trial
Introduction: Corticosteroids and Intravenous immunoglobulin (IVIg) are effective as initial treatment in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but their long-term use is less de...