Immunohistochemical Expression of Matrix Metalloproteinase-2 (MMP-2) in Benign Ovarian Cyst at Adam Malik General Hospital in 2017
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Objective: To determine the immunohistochemical expression of matrix metalloproteinase-2 (MMP-2) in benign ovarian cyst tissue at Adam Malik General Hospital in 2017 Material and Method: This study was an retrospective observational analytic study with a cross sectional design in 22 cases of benign ovarian cysts undergoing gynecological surgery at Adam Malik General Hospital Medan in 2017. Subjects were recruited based on inclusion criteria. Data were collected from medical records and immunohistochemical results which showed tissue MMP-2 expression, then analyzed using descriptive statistics and chi-square test with a significance value of P<0.05. Result: Most subjects with benign ovarian cysts at the age of 20-50 years, non- menopausal, had children ≥1 and normal body mass index. The highest histopathological distribution of benign ovarian cysts with epithelium types, namely mucinouscystadenoma. There was no significant relationship between age, age of menarche, menopause status and body mass index with immunohistochemical expression of MMP-2 in benign ovarian cyst. There was no significant relationship between histopathological subtypes of benign ovarian cysts with MMP-2 immunohistochemical expression. Immunohistochemical expression of MMP-2 in benign ovarian cyst tissue mostly showed negative results (59%). Conclusion: Immunohistochemical expression of MMP-2 was negative in benign ovarian cyst tissue
Authors and Affiliations
Isnayu . , Delfi Lutan, Indra G Munthe, Christoffel L Tobing, Iman Helmi Effendi, Cut Adeya Adella
Keywords
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- EP ID EP464317
- DOI 10.9790/0853-1802017782.
- Views 49
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