Immunohistochemical Study of MUC1, MUC2 and MUC5AC Expression in Primary Breast Carcinoma
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 4
Abstract
Introduction: Breast Cancer (BC) is the second most common cancer among women in India and accounts for 7% of global burden of BC and one-fifth of all Cancers (CA) among women in India. Aim: This study was conducted for studying the expression of MUC1, MUC2 and MUC5AC in breast carcinoma. Materials and Methods: Fifty cases of primary breast carcinoma diagnosed between years 2013 to 2015 were included in the study. Manual tissue array technique was applied for cases subjected to Immunohistochemistry (IHC). An analysis of the expression of IHC markers (MUC1, MUC2, MUC5AC, ER, PR and HER2/neu) was attempted. Results were subjected to statistical analysis. They were considered to be significant when the p-value was less than 0.05. Results: The positivity for MUC1, MUC2 and MUC5AC in BC was 58%, 8% and 6% and for ER, PR and HER2 was 48%, 36% and 64% respectively. There was a significant correlation between MUC1 expression and ER and PR positivity. There was a significant correlation between MUC2 expression and ER positivity. No significant association was observed between MUC2 and PR expression, MUC5AC expression and ER and PR positivity. There was statistically significant correlation between negative MUC2 and MUC5AC expression and histopathological grade. It was noted that MUC2 and MUC5AC negative tumours were associated with higher tumour stage though not statistically significant. It was noted that MUC5AC negative tumours showed higher frequency of lymphovascular invasion though not statistically significant. Conclusion: Our experience with the present study highlights the role of mucins in the development and progression of BC.
Authors and Affiliations
Daxesh Shivabhai Patel, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Maithili Mandar Kulkarni, Bhagyashree Dhande, Pranoti Lengare, Lokesh Ashok Phegade, Ketan Narkhede
Keywords
Related Articles
- EP ID EP337170
- DOI 10.7860/JCDR/2017/26533.9707
- Views 120
- Downloads 0
Receiver Operator Characteristic Analysis of Biomarkers Evaluation in Diagnostic Research
ABSTRACT Receiver Operator Characteristic (ROC) analysis is the choice of method in evaluation of biomarkers in bioinformatics research. However, there is no single method and also no single accuracy index in evaluating...
Posterior Right Sectoral Duct Downstream of the Cystic Ductal Opening: A Rare Variant
The anatomical variants of the posterior right sectoral duct of the biliary tract are frequent. They have a surgical importance involvement. We report a case of 63-year-old female patient operated by laparoscopy for acut...
Correlation of HDL Associated Paraoxonase 1 with Oxidative Stress Markers in Hypertensive Dyslipidemic Patients
ABSTRACT Introduction: Paraoxonase 1 (PON 1) is an esterase, exclusively synthesised by the liver and a high density lipoprotein-associated antioxidant enzyme. Aim: To determine the PON 1 and oxidative stress markers a...
Systemic Lupus Erythematosus with Acute Pancreatitis as an Initial Presentation
ABSTRACT Systemic Lupus Erythematosus (SLE) is an autoimmune, chronic inflammatory disorder affecting mainly the women. Almost half of the SLE patients have gastrointestinal involvement. SLE associated gastrointestinal s...
Perceptions of Patients and Physicians Regarding Need for Taking Ayurveda Therapy
ABSTRACT Introduction: Globally there is great awareness about complementary health systems and its integration. Ayurveda is nowadays being increasingly preferred by patients; however, reasons for patients need to attend...