Immunohistochemical study of receptor status in breast carcinoma and their correlation with histopathological grading
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 8, Issue 2
Abstract
Background and Objectives: Breast carcinoma is the second most common cancer in many parts of India. The prognosis and management of breast carcinoma is influenced by factors like stage, grade, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor -2/neu (Her-2/neu) status. The objectives of the study were to assess the expression of ER, PR and Her-2/neu hormone receptor status in breast carcinoma and to correlate with histologic grade by Nottingham modification of Bloom–Richardson grading system. Materials and Methods: In the present study 60 primary breast carcinoma cases were included. Hematoxylin and Eosin stained slides were studied and histopathologic type was determined. ER/PR and Her2/neu status was assessed to see the total score and correlated with histopathologic grade. Chi- square test was used to see the association between hormonal receptor status and grade. For all statistical analysis P value < 0.05 was considered significant. Results: Out of 60 cases the most frequent histologic grade was II (35.0%). On IHC 26.67% of cases were ER/PR positive and 68.33% were ER/PR negative. All the ER/PR positive cases were of grade I or II and none in grade III. Fifty two percent (52%) of triple negative cases were of grade III. The frequency of triple negative cases was also high. The study showed significant correlation between receptor status and grade of the tumor (P value <0.001). Conclusion: Hormonal receptor status is low in the present study compared to western countries. Majority of low grade tumors were ER/PR positive and majority of the grade III were triple negative. The frequency of triple negative cases was also higher in our study. Hormonal receptor studies are strongly recommended for treatment and prognosis breast carcinoma.
Authors and Affiliations
M N Jadhav, Kempula G, S K Kittur
Keywords
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- EP ID EP457200
- DOI 10.26611/1058212
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