Immunohistochemical study of receptor status in breast carcinoma and their correlation with histopathological grading
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 8, Issue 2
Abstract
Background and Objectives: Breast carcinoma is the second most common cancer in many parts of India. The prognosis and management of breast carcinoma is influenced by factors like stage, grade, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor -2/neu (Her-2/neu) status. The objectives of the study were to assess the expression of ER, PR and Her-2/neu hormone receptor status in breast carcinoma and to correlate with histologic grade by Nottingham modification of Bloom–Richardson grading system. Materials and Methods: In the present study 60 primary breast carcinoma cases were included. Hematoxylin and Eosin stained slides were studied and histopathologic type was determined. ER/PR and Her2/neu status was assessed to see the total score and correlated with histopathologic grade. Chi- square test was used to see the association between hormonal receptor status and grade. For all statistical analysis P value < 0.05 was considered significant. Results: Out of 60 cases the most frequent histologic grade was II (35.0%). On IHC 26.67% of cases were ER/PR positive and 68.33% were ER/PR negative. All the ER/PR positive cases were of grade I or II and none in grade III. Fifty two percent (52%) of triple negative cases were of grade III. The frequency of triple negative cases was also high. The study showed significant correlation between receptor status and grade of the tumor (P value <0.001). Conclusion: Hormonal receptor status is low in the present study compared to western countries. Majority of low grade tumors were ER/PR positive and majority of the grade III were triple negative. The frequency of triple negative cases was also higher in our study. Hormonal receptor studies are strongly recommended for treatment and prognosis breast carcinoma.
Authors and Affiliations
M N Jadhav, Kempula G, S K Kittur
Ki-67 expression in the lesions of uterine cervix
Background: Malignant transformation and uncontrolled cellular proliferation are the key factors in the development of cervical cancers. The aim of this study was to assess the proliferative activity by using Ki-67 proli...
Morphological and histopathological changes in heart
Background: Cardiac pathology, all over the world is largely autopsy based. A detailed gross study of the heart with photographic records, and histological analysis is still the gold standard for confirmation of ante mor...
Parosteal ossifying lipoma of scapula - A rare case report
Parosteal lipoma (ones having contiguity with the periosteum) is a rare subtype of lipoma. The Ossifying lipoma (with osseous element) is also rare entity. We present a case of Parosteal Ossifying lipoma at scapula, whic...
Clinicopathological study of oral cancers in a rural area - A two year study
Background: Oral cancer is one of the ten most common cancers in the world and in India it is one of the top five leading cancers in either gender. It can be easily detected at an early stage with careful clinical examin...
Histopathological study of non-neoplastic and neoplastic skin lesion by punch biopsy in west India - A three year study
Background: Dermatological disorders are common in all countries but the spectrum varies greatly with wide histological variation including both benign and malignant forms. Accurate diagnosis of skin disorders is of utmo...