Ki-67 expression in the lesions of uterine cervix
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 7, Issue 2
Abstract
Background: Malignant transformation and uncontrolled cellular proliferation are the key factors in the development of cervical cancers. The aim of this study was to assess the proliferative activity by using Ki-67 proliferative marker. Methods: We used immunohistochemical methods to study the expression of Ki-67 in the specimens of 14 Patients of cervicitis, 6 patients of LSIL, 6 Patients of HSIL and 14 atients of squamous cell carcinoma. Results: Ki-67 showed positivity in lower one third of epithelium in all the 14 patients of non specific cervicitis, positivity in lower two third of epithelium in all 6 patients of LSIL and 6 patients of HSIL. Also, Ki-67 was positive in entire thickness in all cervical carcinoma patients. This observation points that Ki-67 being the index of cell growth fraction is found to increase with increase in cell proliferation which in turn indicates the degree of malignancy. Conclusion: This study showed Ki-67 is positively associated with increase in grades of cervical lesions and carcinoma cervix with statistically significant p value of 0.001. Ki-67 antigen could be an important factor to identify women at higher risk for progression to cervical cancer.
Authors and Affiliations
Shivapriya R, Niharika Rawat
Keywords
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