Immunohistochemical study on the location of C cells
Journal Title: Indian Journal of Clinical Anatomy and Physiology - Year 2017, Vol 4, Issue 4
Abstract
Introduction: C cells have been predominantly documented to be parafollicular in position in the thyroid. However, C cells have also been reported to occur in the interfollicular space, but this has also been attributed to misinterpretation of tangential sections. Aim: To study the location of C cells in normal and pathological conditions of the thyroid. Materials and Method: Immunohistochemical study using calcitonin rabbit polyclonal antibody was performed in a total of 191 thyroid specimens (38 normal, 44 multinodular goiter, 31colloid goiter, 42 papillary carcinoma(Ca.) thyroid and 36 Hashimotos thyroiditis). Observation: In all the normal and pathological conditions of the thyroid, which showed C cells but with no overt C cell hyperplasia(CCH), the C cells were found parafollicular in position. However, there were instances where C cells were also found well within the colloidal lumen, as in 2 cases of colloid goiter. C cells were predominantly parafollicular/ intrafollicular in all cases exhibiting CCH with the exception that interfollicular nodular C cell proliferations were observed in a case of papillary Ca. thyroid and a case of Multinodular goitre. Conclusion: C cells always are in their native intra or parafollicular position in normal states and predominantly tend to remain so in hyperplastic states as well. However, in certain hyperplastic conditions, they can also form nodules that appear in the interfollicular space or interstitium. C cells can rarely also be found in the colloidal lumen. Such cells could possibly derive their origin from stem endodermal cells and thereby possess an inherent ability to traverse the basement membrane.
Authors and Affiliations
Kafeel Hussain, Swayam Jothi
Keywords
Related Articles
- EP ID EP295038
- DOI 10.18231/2394-2126.2017.0129
- Views 54
- Downloads 0
Lobulated spleen with a fissure on diaphragmatic surface
During my dissection classes, a bi-lobed and large lobulated spleen with a deep vertical fissure measuring 2cms deep was observed. Fissure is in between superior and inferior border i.e. in diaphragmatic surface. As it i...
Gender differences on pain threshold, body temperature and reaction time among elderly population after alternate nostril breathing exercises-A comparative study
Introduction It is a known fact that elderly males have a faster reaction time than females and females exhibit greater pain sensitivity than males Results on body core temperature between genders are inconsistent Altern...
Anatomical learning
Learning Anatomy is more important for the understanding of Medical Science amp more for the contribution in basic research1 An individual history could give a status amp method which were prevalent during those day when...
Students' perspective of their postings in cardiology during early clinical exposure
Introduction: Information regarding conduct and evaluation of Early Clinical Exposure (ECE) which has been mandated by Medical Council of India, is scarce and the present study is an attempt to highlight the significance...
Study of pulmonary function test in hypothyroidism
Introduction thyroid disorders are very common worldwide and there is steep rise in thyroid disorders in India as well1 There are very few studies done in past to evaluate effect of thyroid disorder on pulmonary function...