Immunohistochemistry in breast carcinoma
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 3
Abstract
Introduction Breast Carcinoma has emerged as most common type of malignant tumor in women surpassing cervical carcinoma which was commonest few decades ago Hence a proper diagnostic protocol is very much necessary for diagnostic management and prognostic purposes Immunohistochemistry has helped to some extent in this aspectMaterials and Methods Both HE stained sections and IHC sections for ER PR and Her2 were studied The Hormone receptor status was correlated with age grade and type of tumorResults Total cases analyzed in the present study were 50 Infiltrating ductal carcinoma was 455090 and others were 55010 IDC was the most common one and triple negative tumors being 3483 Hormone receptor status was more in younger patients than older ones And there was positive association with smaller size of the tumors Their expression was higher in grade I tumors at 85 than in grade III tumors at 10 The smaller tumors less than 2cm showed triple positively more frequently than larger tumors more than 2cmConclusion In the present study the breast carcinoma in younger patients having smaller size of tumor was frequently positive for ER PR and negative for Her2neu than older patients with larger size of the tumor Immunohistochemical study of breast carcinoma must be routine so as to help the clinician for better management of patients Keywords Breast carcinoma Infiltrating duct carcinoma Immunohistochemistry IHC Estrogen receptor ER Progesterone receptor PR Human epidermal growth factor receptor2HER2
Authors and Affiliations
Gireesh V. Achalkar
Keywords
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- EP ID EP475912
- DOI 10.18231/2394-6792.2018.0080
- Views 92
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