Immunohistochemistry of Kikuchi Fugimoto Disease.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 3
Abstract
Background Kikuchi Fujimoto Disease (KFD) Is A Self Limiting Sub Acute Necrotizing Regional Lymphadenopathy Associated With Mild Fever. It Is More Common In Young Females Of Asian Origin. KFD Has To Be Differentiated From Other Necrotizing Lymphadenopathies Such As Tuberculosis, Lupus Erythematosus, And Some Lymphomas, Since Their Course And Treatment Are Entirely Different. Hence, This Study Intends To Delineate The Immunohistochemical Profile Of Kikuchi Fujimoto Disease In Order To Aid In Differentiating It From Others. Aim To Describe The Presence Or Absence Of Different Histomorphological Features And Immunohistochemical Markers In Relation To The Topography Of The Nodes In The Different Histological Subsets Of The Disease Material and Methods 25 Cases Of Kikuchi Fugimoto Disease, Diagnosed By Histopathological Features, Were Selected. The Clinical Details And Histopathological Features, Including Presence Of Architectural Effacement Of Lymph Node, Follicular Hyperplasia, Paracortical Hyperplasia, Proliferation Centres, Geographic Necrosis, Apoptosis And Foam Cells, Were Analysed. Immunohistochemistry (IHC) Was Done In All 25 Cases And Expression Of 10 IHC Markers In The Cells Were Noted And Analysed. Results and Conclusions Diagnosis Of Kikuchi-Fujimoto Disease Largely Relies On The Histomorphological Features, Especially The Presence Of Necrosis And Apoptotic Debris With Plenty Of Histiocytes And Almost Complete Absence Of Neutrophils And Eosinophils. Cytoplasmic MPO Positivity In Histiocytes Is Helpful In Differentiating Kikuchi-Fujimoto Disease From Other Necrotizing Lymphadenitis And Lymphoma, Although It Cannot Differentiate It From Lupus Lymphadenitis. CD30 Expression Is Typically Absent Within Histiocytes In Kikuchi-Fujimoto Disease, Which Can Differentiate The Above From Several Lymphomas.
Authors and Affiliations
Dr. Bindu C. S.
Keywords
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