Immunological reactivity in patients with chronic diffuse liver diseases
Journal Title: Гастроентерологія - Year 2018, Vol 52, Issue 4
Abstract
Background. The aim of the study was to assess the state of the main indicators of cellular immunity and the level of cytokines in patients with chronic diffuse liver diseases (CDLD). Materials and methods. Sixty eight patients with CDLD were examined, they were divided into 4 groups depending on the etiological factors of the formation and progression of steatosis and liver fibrosis: group I — 36 patients with non-alcoholic fatty liver disease; group II — 13 persons with chronic viral hepatitis C, group III — 14 patients with alcoholic liver disease, IV group — 5 individuals with toxic hepatitis. We studied the main indicators of cellular immunity and the level of interleukin (IL) 6, IL-10 and tumor necrosis factor (TNF) α. Results. In 83.3 % of patients in group I, 76.9 % — in group II and in a half of patients in group III, there was a significant decrease in the T helper cell subpopulation. Cellular immunodeficiency in patients with CDLD leads to the formation of steatosis. In 69.2 % of patients in group II, immunoregulatory disorders indicate the persistence of hepatitis C virus and, as a consequence, the development of fibrosis. According to the results obtained, the concentration of TNF-α in patients of groups I, II and IV significantly exceeds the control values — by 6.9, 7.9 and 11.0 times, respectively (p < 0.05). The level of IL-6 is significantly higher (by 3.9 times; p < 0.05) in patients of group I compared with group IV. This indicates the progression of the immunopathological process and is a pathogenetic sign of the inadequacy of the immune system functioning in CDLD. Conclusions. The study shows that the progression of liver steatosis is accompanied by a decrease in cellular immune system and an increase in proinflammatory cytokine levels
Authors and Affiliations
O. M. Tatarchuk, V. I. Didenko, S. L. Melanich, V. Ye. Kudryavtseva
Keywords
Related Articles
- EP ID EP440813
- DOI 10.22141/2308-2097.52.4.2018.154142
- Views 92
- Downloads 0
Molecular Features of Inflammation of the Gastric Mucosa in Children with Helicobacter pylori Infection Associated with CagA(+) Strains of H.pylori
Objective. To evaluate the role of NF-κB and factors of recognition innate immunity (TLR4, sCD14) in the development of inflammation of the gastric mucosa (GM) in children with chronic gastroduodenal diseases, depending...
State of cavity microbiota of the colon in breastfed children with acute enterocolitis with infection of breast milk
Background. Despite the significant progress made in the field of acute enterocolitis in children, many questions of etiology, pathogenesis, microecological relations, formation of intestinal dysbacteriosis/dysbiosis and...
Optimizing of duodenogastric reflux therapy in patients with chronic gastritis
Background. The known methods of duodenogastric reflux treatment which include prokinetics administration against the background of chronic gastritis standard therapy, as a rule, have the low therapeutic efficacy. The ai...
Clinical and hemodynamic aspects of hepatic and extrahepatic portal hypertension
Background. Significant variability of the quantitative indices of portal blood flow in chronic hepatitis, cirrhosis, chronic heart failure, Budd-Chiari disease confirms the need for further search for clinical and hemod...
Experience in the Use of Psychocorrection Therapy in the Comprehensive Treatment of Patients with Gastroesophageal Reflux Disease Combined with Dysfunction of the Biliary System
Nowadays, due to the rapid increase in the number of stress factors, it is especially important to use psychotherapy and psychopharmacotherapy in the combination treatment of patients with diseases of the gastrointestina...