Immunomodulatory activity of Siddha Herbo-Mineral formulation of Rasa Chendhuram in RAW Cell line
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 11
Abstract
The term ‘immunity’ has traditionally referred to the resistance exhibited by the host towards injury caused by microorganisms and their products. The immune response to an antigen, whatever its nature, can be of two broad types-Humoral mediated immunity and Cell mediated immunity. Macrophages, important components in the human immune defense system, respond actively to inflammation by releasing Pro-inflammatory cytokienes, such as TNF- ᾳIL-1,6, high levels of these cytokienes can cause systemic complications. Chronic inflammatory disorders such as Rheumatoid arthritis, Psoriasis, SLE, asthma diseases result in the production of several cytokienes. These can recruit activated inflammatory and immune cells to the involved site and thereby amplify and perpetuate the inflammatory process. B cells and T cells are the major types of lymphocytes and are derived from haematopoietic stem cells in the bone marrow, Thymus(T-Lymphocytes) and Spleen. To evaluate the immunomodulatory activity of RCM using Macrophage cell line RAW264.7 using lipopolysacchrides (LPS)(1µg/ml) as a control.]While the concentration level is decreased, nitrate level increased. Hence 25µg/ml of RCM has rich level of nitrate and thus proven to be an Immumomodulator.
Authors and Affiliations
Aruna. C*¹ and Mohamed Musthafa M ²
Keywords
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- EP ID EP570729
- DOI 10.22192/ijcrms.2017.03.11.003
- Views 125
- Downloads 0
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