The identification of HPV, CMV, HSV and EBV Infections and P53 Expression in Esophageal Squamous Cell Carcinoma in Gadarif Teaching Hospital (2014- 2017)
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 1
Abstract
Background; Esophageal carcinoma is not common disease in Sudan especially in eastern Sudan although it is neglected and patients usually presented at late stages of the disease. The main aim of this study is to identify the demographic, clinical and laboratory risk factors in Gadardif state and to determine their association with this disease and to evaluate the role of HPV, CMVs, HSV and EPV viruses and assess the expression of P53 protein in Squamous cell carcinoma of the esophagus. Materials and Methods; This was a prospective analytical cross sectional study of one hundred and fifty patients for whom endoscopic examination was done, esophageal tissue biopsy was taken and examination was performed for these biopsies. Tissue sections prepared and were subjected to detection of HPV, HSV, CMV, EBV infections and P53 by using immunohistochemistry techniques (IHC). Result; HPV infection was detected in Fifty eight (38.7%) it was positive in 21(24.1%) diagnosed as poor differentiated esophageal carcinoma and negative in 66(75.9%) of them P value 0.01. Twenty one (14%) was diagnosed positive for CMV infection 5 of them was diagnosed as well differentiated esophageal carcinoma and it was positive in 16(18.4%) diagnosed as poor differentiated esophageal carcinoma P value 0.09 . Twenty (13.3%) of them were diagnosed positive for HSV infection 3 (4.8) of them diagnosed as well differentiated esophageal carcinoma and it was positive in 17(19.5%) diagnosed as poor differentiated esophageal carcinoma P value 0.01. Fifteen (10%) of them were diagnosed positive for EBV infection 1 (1.6) of them was diagnosed as well differentiated esophageal carcinoma and it was positive in 14(16.1%) diagnosed as poor differentiated esophageal carcinoma P value 0.004. Twenty five (16.7%) of them were diagnosed positive for P53 expression 6(9.5%) of them was diagnosed as well differentiated esophageal carcinoma and at P value 0.07. Conclusions; Here, we summarize there was association between HPV and HSV infections and the grade of esophageal carcinoma.
Authors and Affiliations
Nadia Abdel Rahiam Mohammed Alamin , Usama A Elsharief , Rabie A Babiker , Osman Khalafallah Saeed Mahmoud Ibrahim Osman Hamad , Osman Sadig Bukhari , Sami Eldirdiri Elgaili Salah , Mawa Bushra Omer
Keywords
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- EP ID EP550446
- DOI 10.22192/ijcrms.2018.04.01.017
- Views 120
- Downloads 0
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