Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 4
Abstract
In this study, high-density arrays (576 microneedles on a 5 × 5-mm backplate, gifted by Bosch, Germany, Stuttgart) with a microneedle length of 200 μm were used (Fig. 1 ). The microneedles were applied onto ex vivo human abdominal skin that was obtained from hospitals within 24 h after cosmetic surgery and dermatomed to a thickness of 600 μm (11). To investigate factors that influence the penetration efficiency, microneedles were applied onto the skin for 10 s with different forces (3.43–22.1 N) by applying weight rods (350–2,250 g) onto the insertion device for manual application. Also, the effect of application time (5–60 s) with a constant force (7.36 N) was investigated. Next, 15 participants (21–57 year; 10 male and 5 female) volunteered to apply a microneedle array three times onto ex vivo human skin, in a direction perpendicular to the skin surface, by using either a manual application device (Fig. 1d ), or an impact-insertion applicator at a velocity of 3 m/s (Fig. 1e ) (12). The type of microneedle application was randomly performed.
Authors and Affiliations
Koen van der Maaden, Emine Sekerdag, Wim Jiskoot, Joke Bouwstra
Keywords
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