Impact of Early Addition of Teneligliptin to Metformin in Type 2 Diabetic Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Diabetes is a noncommunicable disease. Present study assessed the effectiveness of early addition of Cost effective teneligliptin to Metformin in Type 2 Diabetes Mellitus patients. Material and Methods: 100 subjects were enrolled, of which only 28 subjects were eligible for the study. The study group comprised of 28 subjects who were on metformin monotherapy i.e. between 1000gms to 2000gms per day. 500 mg of metformin in the study group was replaced with DPPIV inhibitor- teneligliptin 20mg per day. In order to study the efficacy of combination therapy versus metformin monotherapy Paired t test was performed after completion of 12weeks of therapy. Result: The efficacy of combination therapy was assessed by Paired t test. It was observed that the mean FBS after addition of teneligliptin was (109.36 mg/dl ± 10.92) when compared to (118.07mg/dl ±12.76) in the Metformin monotherapy (t value: 4.98; p value <0.001) there was significant decrease in Fasting blood glucose level after addition of teneligliptin. The mean PPBS after addition of teneligliptin was (182.61 mg/dl ±33.05) when compared to (203.18mg/dl ±38.04) in the Metformin monotherapy (t value: 7.76; p value <0.001) there was significant decrease in post prandial blood glucose level after addition of teneligliptin. The mean baseline HbA1c after addition of teneligliptin was (7.44% ±0.35) when compared to (7.65% ±0.38) in the Metformin monotherapy (t value: 7.12; p value <0.001) there was significant decrease in HbA1C level after addition of teneligliptin. The incidence of Gastro-intestinal adverse events was more in metformin monotherapy than addition of teneligliptin however it was not statically significant. In addition there was no statically significant change observed with respect to lipid profile, body weight, Insulin Levels and HOMA score. Conclusion: Teneligliptin was selected for the study because it has longer half-life, dual mode of elimination, superadded it is cost effective and cheaper in India than compared to other DPPIV inhibitors, due to its cheaper cost the compliance was better with respect to usage of teneligliptin. Ultimately Teneligliptin add-on to Metformin during the early course of treatment would be a multimodal approach in treatment of Diabetic patients further it could help in delaying the exhaustion of pancreatic islet function.
Authors and Affiliations
Mansoor Ali Khan Lodhi, Anjum Sultana Khatoon
Keywords
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