Impact of Experimental Development of Arterial Hypertension and Dyslipidemia on Intravascular Activity of Rats’ Platelets
Journal Title: Annual Research & Review in Biology - Year 2017, Vol 14, Issue 5
Abstract
Great interest is shown by researchers to functional and rheological features of basic regular blood elements. Platelets are among them and take the most active part in hemostasis at rather wide-spread nowadays cardio-vascular and metabolic diseases. The aim is to analyze dynamics’ strengthening of platelets' intravascular activity of rats in conditions of experimental consequent development of arterial hypertension and dyslipidemia. The study used 68 male-rats of Vistar line at the age of 2.5-3 months. Control group was composed of 33 animals. Experimental animals (35 rats) were developed at first – arterial hypertension (usage of cardioangiol pathogenic diet for 2 weeks and impact of cold at the end) and then - dyslipidemia (application of rich in calories diet at lowering of motor activity). The rats from experimental group were examined 5 times during the research. The rats from control group were examined twice - at the beginning and at the end of the experiment. While examining experimental and control rats we applied biochemical, hematological and statistical methods of investigation. At consequent arterial hypertension and dyslipidemia development experimental rats had gradual strengthening of lipids' peroxidation processes in plasma (acylhydroperoxides increased in 2.1 times) and platelets (acyl hydroperoxides increased in 1.4 times). Already at arterial hypertension development rats' blood was noted to have lowering of discocytes' quantity on 5.9%, deepening during the further dyslipidemia development on 7.4% more, and reaching 24.6±0.13%. This process was accompanied by gradual increase of activated platelets' sum on 75.7% during the whole period of investigation. The number of small, middle and large platelet aggregates, freely circulating in blood during modeling of double pathology, gradually increased in 2.8 times and in 10.3 times, respectively. Control rats had stable normal level of relevant biochemical and hematological characteristics. Subsequent development of at first arterial hypertension and then – dyslipidemia in rats gradually weakened their antioxidant protection of blood plasma and platelets and strengthened POL processes in them. It also strengthened lipids' peroxidation in them. Developing abnormalities gradually strengthened intravascular platelets' activity and their aggregative ability in experimental animals. The created model allowed tracking the earliest symptoms of strengthening of platelets’ intravascular activity against the background of AH and dyslipidemia development.
Authors and Affiliations
I. A. Skoryatina, S. Yu Zavalishina
Keywords
Related Articles
- EP ID EP313561
- DOI 10.9734/ARRB/2017/33758
- Views 70
- Downloads 0
Germination Characteristics of Parinari curatellifolia Planch. Ex Benth, Vitex doniana Sweet and Zanthoxylum zanthoxyloides (Lam) Watermann Seeds
Germination characteristics studies of seeds of three local species in Burkina Faso namely Parinari curatellifolia, Vitex doniana and Zanthoxylum zanthoxyloides have been carried out. The aim of this study was to carry o...
Study on Antioxidant and Cytotoxic Activities of Methanolic and Ethyl Acetate Extracts of Peel and Seed of Diospyros blancoi
The present study was aimed at investigating the phytoconstituents in order to correlate the folkloric claims with the bioactive compounds present in Diospyros blancoi. Antioxidant and cytotoxic activities of Diospyros b...
Nutrients In situ Degradability of Almond Hulls and Cucumber Wastes from Greenhouse
Aims: Information about degradability of nutrients, effective degradability (ED) values and digestion kinetics of agricultural wastes is important for feed manufacturing industry and farmers performing feed mixing practi...
A Novel Heart Disease Prediction System Based on Quantum Neural Network Using Clinical Parameters
Aims: The diagnosis of Heart disease at earliest possible stage is very crucial to increase the chance of successful treatment and to reduce the mortality rate. The interpretation of cardiovascular disease is time-consum...
Water Physico-chemical Characteristics, Species Diversity and Density of Zooplankton in Two Perennial Lakes of Coimbatore City (India)
In order to assess the suitability of the Ukkadam lake (Lat. 10.99° N and Long. 76.96° E) and the Singanallur lake (Lat. 10.59° N and Long. 77.88° E) of Coimbatore (Tamil Nadu, India) for inland aquaculture, the species...